152981-64-1

Basic information

• Product Name: 2-(4-Phenoxy-phenoxy)-propionic acid ethyl ester
• Synonyms: 2-(4-Phenoxy-phenoxy)-propionic acid ethyl ester
• CAS NO: 152981-64-1
• Molecular Weight: 286.328
• Mol File: 152981-64-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-Phenoxy-phenoxy)-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Phenoxy-phenoxy)-propionic acid ethyl ester(152981-64-1)
• EPA Substance Registry System: 2-(4-Phenoxy-phenoxy)-propionic acid ethyl ester(152981-64-1)

Safety Data

• Hazardous Substances Data: 152981-64-1(Hazardous Substances Data)

Upstream product

• 831-82-3 4-Phenoxyphenol 
• 535-13-7 2-chloro-propanoic acid, ethyl ester 
• 60631-86-9 Potassium; 4-phenoxy-phenolate 
• 535-11-5 Ethyl 2-bromopropionate 

Downstream Products

• 158141-22-1 2-(4-Phenoxy-phenoxy)-propionyl chloride 
• 88355-06-0 propionaldehyde oxime O-2-(4-phenoxyphenoxy)propyl ether 
• 1028280-21-8 3-(4-Ethyl-phenyl)-2-methyl-2-(4-phenoxy-phenoxy)-propionic acid ethyl ester 
• 1027736-04-4 3-(4-Chloro-phenyl)-2-methyl-2-(4-phenoxy-phenoxy)-propionic acid ethyl ester 
• 134227-44-4 2-(4-Phenoxy-phenoxy)-propan-1-ol 
• 51338-26-2 2-(4-phenoxy-phenoxy)-propionic acid 

Relevant articles and documents

Glucose transport-enhancing and hypoglycemic activity of 2-methyl-2- phenoxy-3-phenylpropanoic acids

A series of 2-phenoxy-3-phenylpropanoic acids has been prepared which contains many potent hypoglycemic agents as demonstrated by assessing glucose lowering in ob/ob mice. Some compounds (32, 33, 59) normalize plasma glucose in this diabetic model at doses of approximately 1 mg/kg. The mechanism of action of these drugs may involve enhanced glucose transport, especially in fat cells, but the compounds do not stimulate GLUT4 translocation and do not increase the levels of GLUT1 or GLUT4 in vivo. Thus, these compounds may enhance the intrinsic activity of the glucose transporter GLUT1 or GLUT4. Some compounds also modestly decrease hepatocyte gluconeogenesis in vitro, but this is not likely to be a major contributor to the hypoglycemic effect observed in vivo. Likewise, a modest decrease in food consumption observed with some of these compounds was shown by a pair-feeding experiment not to be the primary cause of the hypoglycemia observed.

Antiphlogistic aryloxypropionic acids: Configurational study

Configurational relationships of a series of antiphlogistic 2-aryloxypropionyl derivatives by means of 1H-NMR and HPLC methods were demonstrated. NMR spectra of racemic mixtures and optically active esters were recorded by adding suitable quant