1529810-92-1

Basic information

• Product Name: (1E,4Z,6E)-7-(4-chlorophenyl)-1-{3-[(dimethylamino)methyl]-4-hydroxyphenyl}-5-hydroxyhepta-1,4,6-trien-3-one
• Synonyms: (1E,4Z,6E)-7-(4-chlorophenyl)-1-{3-[(dimethylamino)methyl]-4-hydroxyphenyl}-5-hydroxyhepta-1,4,6-trien-3-one
• CAS NO: 1529810-92-1
• Molecular Weight: 383.875
• Mol File: 1529810-92-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1E,4Z,6E)-7-(4-chlorophenyl)-1-{3-[(dimethylamino)methyl]-4-hydroxyphenyl}-5-hydroxyhepta-1,4,6-trien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1E,4Z,6E)-7-(4-chlorophenyl)-1-{3-[(dimethylamino)methyl]-4-hydroxyphenyl}-5-hydroxyhepta-1,4,6-trien-3-one(1529810-92-1)
• EPA Substance Registry System: (1E,4Z,6E)-7-(4-chlorophenyl)-1-{3-[(dimethylamino)methyl]-4-hydroxyphenyl}-5-hydroxyhepta-1,4,6-trien-3-one(1529810-92-1)

Safety Data

• Hazardous Substances Data: 1529810-92-1(Hazardous Substances Data)

Upstream product

• 116546-04-4 3-<(dimethylamino)methyl>-4-hydroxybenzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

Design, synthesis and anti-Alzheimer properties of dimethylaminomethyl- substituted curcumin derivatives

Eight dimethylaminomethyl-substituted curcumin derivatives were designed and synthesized. The antioxidant test revealed that the synthesized compounds had higher free radical scavenging activity towards both 2,2-diphenyl-1- picrylhydrazyl free radicals (DPPH) (IC50 1.5-29.9 μM) and galvinoxyl radicals (IC50 4.9-41.1 μM) than the lead compound curcumin. Besides, compound 3a could effectively inhibit the Aβ self-aggregation in vitro. Investigated in phosphate-buffered solutions (pH = 7.4) in the presence or absence of 0.1% FBS 3a showed a good stability while curcumin did not. Furthermore, 3a showed a good lipophilicity (log P = 3.48), suggesting a potential ability to penetrate the blood-brain-barrier. The aqueous solubility of the hydrochloride salt of 3a (16.7 mg/mL) has also been significantly improved as compared with curcumin (0.1 mg/mL).