152996-71-9

Upstream product

• 152996-68-4 (2R,3R)-1-<<(t-butyldimethyl)silyl>oxy>-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-3-<(tri-i-propylsilyl)oxy>butane 
• 152996-69-5 (2S,3R)-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-3-<(tri-i-propylsilyl)oxy>butan-1-ol 
• 152996-67-3 (2R,3R)-4-<<(t-butyldimethyl)silyl>oxy>-3-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-2-butanol 
• 152996-70-8 (2S,3R)-N-Benzyloxy-2-(4-methoxy-benzyloxymethoxymethyl)-3-triisopropylsilanyloxy-butyramide 

Downstream Products

• 152996-73-1 (S)-1-Benzyloxy-3-((R)-1-hydroxy-ethyl)-azetidin-2-one 
• 152996-74-2 (3S,1'R)-1-benzyloxy-3-<<2-(tert-butyldimethylsilyl)oxy>ethyl>-2-azetidinone 
• 152996-72-0 (3S,1'R)-1-benzyloxy-3-<<2-(tri-iso-propylsilyl)oxy>ethyl>-2-azetidinone 

Relevant academic research and scientific papers

Chemoenzymatic Preparation of a Key Intermediate for Carbapenem Synthesis Starting from Asymmetrized Bis(hydroxymethyl)acetaldehyde (BHYMA)

4-Unsubstituted 2-azetidinones 3a,b, which are useful intermediates for the synthesis of carbapenem abtibiotics, have been enantiospecifically and diastereoselectively prepared starting from asymmetrized bis(hydroxymethyl)acetaldehyde (BHYMA) 4, a new chiral building block obtained through biological methods.The key steps are the highly diastereoselective addition of Me2CuLi to 4 (diast. ratio = 95 : 5), and the regioselective deblocking of tBuMe2Si ether in the presence of a (iPr)3Si ether, by using a novel methodology.