152998-05-5

Basic information

• Product Name: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(2-cyanoethyl phosphonate)
• CAS NO: 152998-05-5
• Molecular Formula: C40H39N4O9P
• Molecular Weight: 750.745
• Mol File: 152998-05-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(2-cyanoethyl phosphonate)(CAS DataBase Reference)
• NIST Chemistry Reference: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(2-cyanoethyl phosphonate)(152998-05-5)
• EPA Substance Registry System: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-(2-cyanoethyl phosphonate)(152998-05-5)

Safety Data

• Hazardous Substances Data: 152998-05-5(Hazardous Substances Data)

Upstream product

• 116003-04-4 N₄-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3-O-[O-(2-cyanoethyl)-N,N-(diisopropyl)]phosphoramidite 
• 93134-41-9 N²-isobutyryl-3'-O-levulinyl-2'-deoxyguanosine 
• 404596-20-9 5'-OH-dTps_CNEdT-3'-O-Lev 
• 863507-25-9 5'-OH-dA^Bzps_CNEdT-3'-O-Lev 
• 101187-39-7 1,11-diazido-3,6,9-trioxaundecane 
• 86770-67-4 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol 
• 158041-84-0 2-{2-{2-{2-[bis(4-methoxyphenyl)phenylmethoxy]ethoxy}ethoxy}ethoxy}ethanol 

Downstream Products

• 110237-98-4 5'-(4,4'-dimethoxytrityl)-N⁴-benzoyl-2'-deoxycytidine-3'-H-phosphonate 
• 67219-55-0 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 

Relevant articles and documents

Solution-phase synthesis of branched DNA hybrids via H -phosphonate dimers

A method for the solution-phase synthesis of branched oligonucleotides with tetrahedral or pseudo-octahedral geometry is described that involves the coupling of 3′-H-phosphonates of protected dinucleoside phosphates and organic core molecules. The dimer building blocks are produced by a synthesis that requires no chromatographic purification and that produces the dimer H-phosphonates in up to 44% yield in less than three days of laboratory work. A total of seven different branched hybrids were prepared, including a new hybrid of the sequence (CG)4TBA, where TBA stands for tetrakis(p- hydroxybiphenyl)adamantane that assembles into a material from micromolar aqueous solution upon addition of MgCl2.

High-yield solution-phase synthesis of di- and trinucleotide blocks assisted by polymer-supported reagents

(Chemical Equation Presented) A new solution-phase phosphoramidite approach is reported for oligonucleotide synthesis employing recyclable solid-supported reagents. It uses polyvinyl pyridinium tosylate as the activator of a nucleoside-3′-O-phosphoramidit

Commercially available 5'-DMT phosphoramidites as reagents for the synthesis of vinylphosphonate-linked oligonucleic acids.

[reaction: see text]. Commercially available cyanoethyl phosphoramidites derived from T, d(C), d(A), and d(G) were hydrolyzed (1H-tetrazole, MeCN/H2O) to give the corresponding H-phosphonates in excellent yields. Palladium(0)-catalyzed cross-coupling of e