153025-65-1Relevant academic research and scientific papers
Activation of silylphosphines by diethyl azodicarboxylate: Novel silylation of alcohols
Hayashi, Minoru,Matsuura, Yutaka,Watanabe, Yutaka
, p. 1409 - 1411 (2007/10/03)
A novel activation mode of silylphosphines and an application of that to silylation of alcohols were described. Silylphosphines were found to be instantly activated by means of DEAD and PPTS to form reactive silyl cation equivalents. By using the activate
Preparation of Dipyridylmethane Ligands with Pseudo-C2 Symmetry. Grafting on Polystyrenes via Transformation to Phenolic Derivatives
Levacher, Vincent,Moberg, Christina
, p. 1755 - 1762 (2007/10/02)
Efficient grafting of dipyridylmethane ligands on highly cross-linked as well as gel-type chloromethylated polystyrenes has been achieved using phenolic derivatives of the ligands.In this way, chiral polymer-supported ligands with pseudo-C2 symmetry were obtained.The synthesis of the ligands and their grafting under mild conditions are described, as well as the preparation of monomeric models.During reduction of 6,6'-(2,2-dimethyl-1-oxopropyl) derivatives with sodium borohydride, the R,S isomers were unexpectedly formed with high selectivity.
2-Pyrrolidinone derivatives as HIV protease inhibitors
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, (2008/06/13)
Compounds of the form,ψ ψ A-B-G-Jψ ψ wherein A is an amine protecting group and the like, B an amino acid or analog thereof, wherein G is ψψ ψand J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.ψ
