153029-63-1Relevant articles and documents
Cladinose analogues of sixteen-membered macrolide antibiotics: I. Synthesis of 4-O-Alkyl-L-cladinose analogues via glycosylation
Kurihara, Ken-Ichi,Ajito, Keiichi,Shibahara, Seiji,Ishizuka, Tsuneo,Hara, Osamu,Araake, Minako,Omoto, Shoji
, p. 582 - 592 (2007/10/03)
The synthesis and biological evaluation of sixteen-membered macrolides possessing a 4-O-alkyl-α-L-cladinosyl moiety as the neutral sugar are described. The nine novel derivatives have been synthesized by glycosylation with l-thio sugars. The most active derivative of them showed prolonged antibacterial activity in rat plasma in vitro and improved pharmacokinetics.