153034-80-1Relevant articles and documents
HETEROCYCLIC INHIBITORS OF PTPN11
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Paragraph 0412; 0413, (2018/01/04)
The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their applica
PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS
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Page/Page column 60; 61, (2016/07/05)
The present invention is directed to pyrrolidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
Traceless solid-phase synthesis of mappicine ketone library via multiple chemoselective palladium-catalyzed reactions on benzenesulfonate linker
Tsukamoto, Hirokazu,Suzuki, Risako,Kondo, Yoshinori
scheme or table, p. 2005 - 2010 (2009/04/10)
We report here a solid-phase synthesis of a library of mappicine ketone, a leading antiviral compound with activity against herpes viruses and human cytomegalovirus. The synthesis is based on multiple chemoselective palladium-catalyzed reactions involving