153034-82-3

Basic information

• Product Name: 4-IODO-2-FLUORO-3-FORMYLPYRIDINE
• Synonyms: 2-FLUORO-4-IODONICOTINALDEHYDE;2-FLUORO-4-IODOPYRIDINE-3-CARBOXALDEHYDE;4-IODO-2-FLUORO-3-FORMYLPYRIDINE;2-FLUORO-3-FORMYL-4-IODOPYRIDINE;2-Fluoro-4-iodo-3-pyridinecarboxaldehyde;2 - F -3 - aldehyde -4 - iodine pyridine;2-fluoro-4-iodonicotaldehyde;2-Fluoro-4-iodopyridine-3-carbaldehyde
• CAS NO: 153034-82-3
• Molecular Formula: C₆H₃FINO
• Molecular Weight: 251
• Product Categories: Pyridine;Pyridines;Fluorine series
• Mol File: 153034-82-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 304.229 °C at 760 mmHg
• Flash Point: 137.793 °C
• Appearance: /
• Density: 2.081 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: Room temperature.
• PKA: -3.62±0.18(Predicted)
• CAS DataBase Reference: 4-IODO-2-FLUORO-3-FORMYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-2-FLUORO-3-FORMYLPYRIDINE(153034-82-3)
• EPA Substance Registry System: 4-IODO-2-FLUORO-3-FORMYLPYRIDINE(153034-82-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 153034-82-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 58, p. 7832, 1993 DOI: 10.1021/jo00079a031

InChI:InChI=1/C6H3FINO/c7-6-4(3-10)5(8)1-2-9-6/h1-3H

Upstream product

• 168428-74-8 2-fluoro-4-iodo-3-pyridyllithium 
• 109-94-4 formic acid ethyl ester 
• 22282-70-8 2-fluoro-4-iodopyridine 
• 372-48-5 2-fluoropyridine 
• 113975-22-7 2-fluoro-3-iodopyridine 

Downstream Products

• 1356054-82-4 1-(3-(trifluoromethyl)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylboronic acid 
• 1356054-64-2 3-(4-Iodo-1H-pyrazolo[3,4-b]pyridin-1-yl)benzenesulfonamide 
• 1356054-70-0 1-(2,4-difluorophenyl)-4-iodo-1H-pyrazolo[3,4-b]pyridine 
• 1356054-71-1 ((E)-3-((2-(2,4-difluorophenyl)hydrazono)methyl)-2-fluoro-4-iodopyridine) 
• 1356054-66-4 1-(4-fluorophenyl)-4-iodo-1H-pyrazolo[3,4-b]pyridine 
• 1356054-76-6 4-iodo-1-(2,3,5,6-tetrafluorophenyl)-1H-pyrazolo[3,4-b]pyridine 
• 1356054-77-7 1-(2,3,5,6-tetrafluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-ylboronic acid 
• 1356054-87-9 4-iodo-1-(2-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridine 
• 1356054-88-0 1-(2-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-ylboronic acid 
• 1356054-89-1 4-iodo-1-(2,4,6-trifluorophenyl)-1H-pyrazolo[3,4-b]pyridine 
• 1356054-90-4 (E)-2-fluoro-4-iodo-3-((2-(2,4,6-trifluorophenyl)hydrazono)methyl)pyridine 
• 1356054-91-5 1-(2,4,6-trifluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-ylboronic acid 
• 1356053-56-9 3-(4-(4-methoxypyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)benzenesulfonamide 
• 1356054-44-8 N-cyclopropyl-5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)pyrimidin-4-amine 

Relevant articles and documents

NOVEL ISOINDOLINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

Disclosed are a novel isoindoline derivative, a pharmaceutical composition and use thereof. The compound of formula I, or the pharmaceutically acceptable salt, solvate, polymorph, co-crystal, stereoisomer, isotopic compound, metabolite or prodrug thereof disclosed in the invention can regulate the generation and/or activity of PDE4 and/or TNF-α so as to effectively treat cancer and inflammatory diseases.

PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to pyrrolidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

First Metalation of Aryl Iodides: Directed Ortho-Lithiation of Iodopyridines, Halogen-Dance, and Application to Synthesis

Metalation of iodopyridines was succesfully achieved by LDA at low temperature.In many cases, lithiation is ortho directed by the iodo group which subsequently ortho-migrates very fast to give stabilized iodolithiopyridines.This procedure was applied to 2