153039-16-8

Basic information

• Product Name: 1-Pyrrolidinecarboxylicacid,3,3-diMethyl-2-oxo-,1,1-diMethylethylester
• Synonyms: 1-Pyrrolidinecarboxylicacid,3,3-diMethyl-2-oxo-,1,1-diMethylethylester;tert-butyl 3,3-dimethyl-2-oxopyrrolidine-1-carboxylate;Tert-Butyl 3,3-Dimethyl-2-Oxopyrrolidine-1-Carboxylate(WXC04334)
• CAS NO: 153039-16-8
• Molecular Formula: C11H19NO3
• Molecular Weight: 213.27346
• EINECS: -0
• Mol File: 153039-16-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 311.2±11.0 °C(Predicted)
• Appearance: /
• Density: 1.056±0.06 g/cm3(Predicted)
• PKA: -2.12±0.40(Predicted)
• CAS DataBase Reference: 1-Pyrrolidinecarboxylicacid,3,3-diMethyl-2-oxo-,1,1-diMethylethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylicacid,3,3-diMethyl-2-oxo-,1,1-diMethylethylester(153039-16-8)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylicacid,3,3-diMethyl-2-oxo-,1,1-diMethylethylester(153039-16-8)

Safety Data

• Hazardous Substances Data: 153039-16-8(Hazardous Substances Data)

Usage

Class

The chemical belongs to the class of organic compounds known as pyrrolidine carboxylic acids.

Type

It is an ester derivative of pyrrolidine carboxylic acid.

Uses

The chemical is commonly used in organic synthesis and pharmaceutical research due to its potential biological activity.

Role

It also has a role as an intermediate in the production of other chemicals.

Potential

It may have uses in the development of new drugs and therapeutic agents.

Upstream product

• 4831-43-0 3,3-dimethylpyrrolidin-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 171017-18-8 tert-butyl 3-methyl-2-oxo-1-pyrrolidine-carboxylate 
• 74-88-4 methyl iodide 
• 85909-08-6 tert-butyl 2-oxopyrrolidine-1-carboxylate 

Downstream Products

• 153039-17-9 2,2-dimethyl-4-[[(2-methylpropan-2-yl)oxyoxomethyl]amino]butanoic acid 
• 4831-43-0 3,3-dimethylpyrrolidin-2-one 
• 1246609-91-5 ethyl 6-(4-(tert-butoxycarbonylamino)-2-methylbutan-2-yl)-2-(phenylamino)nicotinate 

Relevant articles and documents

Structural studies of {6Li} 2-lithiopyrrolidines using NMR spectroscopy

A selection of N-substituted 2-lithiopyrrolidines were prepared and their structures were investigated by 6Li and 13C NMR spectroscopy. Evidence is presented for aggregation and dynamic solvation effects, depending on the nature of the N-substituent and substituents on the pyrrolidine ring. Studies were performed with N-Boc (coordinating carbonyl group), N-methoxyethyl (coordinating methoxy group) and N-alkyl (no coordinating group) heterocycles to represent three different classes of organolithiums: dipole-stabilized, unstabilized and chelated, and unstabilized.

4-AMINO OR 4-ALKOXY-SUBSTITUTED ARYL SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.

2-(1-HETEROARYLPIPERAZIN-4-YL)METHYL-1,4-BENZODIOXANE DERIVATIVES AS ALPHA2C ANTAGONISTS

Compounds of formula I (formula I), wherein A is an optionally substituted five-membered unsaturated heterocyclic ring containing 1, 2 or 3 N, O or S ring heteroatom(s) exhibit alpha2C antagonistic activity and are thus useful for the treatment of diseases or conditions of the peripheric or central nervous system.