153080-73-0Relevant academic research and scientific papers
Stereoselective Reactions of Lithium Enolates Derived from N-BOC Protected Pyroglutamic Esters
Ezquerra, Jesus,Pedregal, Concepcion,Rubio, Almudena,Yruretagoyena, Belen,Escribano, Ana,Sanchez-Ferrando, Francisco
, p. 8665 - 8678 (1993)
The lithium enolates of N-Boc protected pyroglutamic ethyl or tert-butyl esters react with electrophiles in good yield without epimerization of the chiral centre.With benzyl bromides the process is stereospecific, yielding exclusively the trans isomer.However, with other reactive electrophiles a 2:1 tans/cis diastereometric mixture was obtained, regardless of the steric bulk of the ester group.
The enantiospecific synthesis of novel lysine analogues incorporating a pyrrolidine containing side chain
Murray, Peter John,Starkey, Ian D.,Davies, John E.
, p. 6721 - 6724 (2007/10/03)
Two novel analogues of lysine have been prepared in high enantiomeric and diastereomeric purity. These unnatural α-amino acids possess modified aminoalkyl side chains incorporating a pyrrolidine nucleus as a cyclic constraint.
