153080-83-2

Upstream product

• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 4392-24-9 Cinnamyl bromide 

Downstream Products

• 363599-64-8 (2S,4R)-1-((R)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionyl)-5-oxo-4-((E)-3-phenyl-allyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 363599-67-1 (2S,4R)-1-((R)-2-tert-Butoxycarbonylamino-3-hydroxy-propionyl)-5-hydroxy-4-(3-phenyl-propyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 363599-65-9 (2S,4R)-1-((R)-2-tert-Butoxycarbonylamino-3-hydroxy-propionyl)-5-oxo-4-(3-phenyl-propyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 363599-68-2 (3R,6S,8R,8aR)-3-tert-Butoxycarbonylamino-4-oxo-8-(3-phenyl-propyl)-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carboxylic acid ethyl ester 
• 363599-66-0 (2S,4R)-5-Oxo-4-((E)-3-phenyl-allyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 284024-88-0 ethyl (2S,4R)-N-Boc-4-(3-phenylpropyl)pyroglutamate 

Relevant academic research and scientific papers

A convenient and versatile synthesis of 6,5- and 7,5-fused bicyclic lactams as peptidomimetics

Chemo-selective reduction of the pyroglutamate ring carbonyl in a serine-pyroglutamate or homoserine to pyroglutamate dipeptide gave a hemiaminal. Treatment of the hemiaminal with a catalytic amount of TFA in CH2Cl2 generated an N-ac

4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists

Enantiomerically pure (2S,4R)-4-substituted glutamic acids were prepared and tested for homomeric GluR5 and GluR6 kainate subtype receptor affinity. Some of the 4-cinnamyl analogues showed high selectivity and potency (K(i) 25 nM) for the GluR5 receptor