153080-86-5Relevant academic research and scientific papers
Design and synthesis of potent, non-peptide inhibitors of HCV NS3 protease
Zhang, Xiaojun,Schmitt, Aaron C.,Jiang, Wen,Wasserman, Zelda,Decicco, Carl P.
, p. 1157 - 1160 (2007/10/03)
Starting from a hexapeptide boronic acid lead, 3-amino bicyclic pyrazinones as novel β-sheet dipeptide mimetics have been designed and synthesized. Side-chain manipulation of this scaffold generated a series of potent, nonpeptidic inhibitors of HCV NS3 protease.
(2S,3S)-2-Amino-3-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist
Escribano, Ana,Ezquerra, Jesus,Pedregal, Concepcion,Rubio, Almudena,Yruretagoyena, Belen,Baker, S. Richard,Wright, Rebecca A.,Johnson, Bryan G.,Schoepp, Darryle D.
, p. 765 - 770 (2007/10/03)
(2S,4S)-2-Amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid 1m, is a novel metabotropic glutamate receptor (mGluR) antagonist with insignificant ionotropic affinity. It is a selective antagonist of negatively-coupled cAMP-linked mGluRs with no effect
Stereoselective Reactions of Lithium Enolates Derived from N-BOC Protected Pyroglutamic Esters
Ezquerra, Jesus,Pedregal, Concepcion,Rubio, Almudena,Yruretagoyena, Belen,Escribano, Ana,Sanchez-Ferrando, Francisco
, p. 8665 - 8678 (2007/10/02)
The lithium enolates of N-Boc protected pyroglutamic ethyl or tert-butyl esters react with electrophiles in good yield without epimerization of the chiral centre.With benzyl bromides the process is stereospecific, yielding exclusively the trans isomer.However, with other reactive electrophiles a 2:1 tans/cis diastereometric mixture was obtained, regardless of the steric bulk of the ester group.
