153083-53-5 Usage
Uses
Used in Cancer Research:
Paclitaxel IMpurity F is used as a research compound for studying the structure and function of microtubules into tubulin. This is important for understanding the mechanisms of cell division and the potential development of new cancer treatments.
Used in Cancer Treatment:
Paclitaxel IMpurity F is used as a mitotic inhibitor in cancer chemotherapy. It is particularly effective in treating patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. The compound works by stabilizing microtubules, preventing cell division and ultimately leading to cell death.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Paclitaxel IMpurity F is used as a reference compound for the development and quality control of Paclitaxel-based drugs. It helps ensure the purity and efficacy of these medications, which are crucial in the fight against various types of cancer.
Used in Drug Development:
Paclitaxel IMpurity F is used as a starting point for the development of new anticancer drugs. Researchers can study its chemical structure and properties to design and synthesize novel compounds with improved pharmacological profiles and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 153083-53-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,0,8 and 3 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 153083-53:
(8*1)+(7*5)+(6*3)+(5*0)+(4*8)+(3*3)+(2*5)+(1*3)=115
115 % 10 = 5
So 153083-53-5 is a valid CAS Registry Number.
153083-53-5Relevant academic research and scientific papers
N-methylation of the C3′ amide of taxanes: Synthesis of N-methyltaxol C and N-methylpaclitaxel
Santhapuram, Hari K. R.,Datta, Apurba,Hutt, Oliver E.,Georg, Gunda I.
, p. 4705 - 4708 (2008/09/21)
(Chemical Equation Presented) A method has been developed for the methylation of the C3′ amide of taxol C and paclitaxel. Taxol C and paclitaxel were sequentially silylated at the 2′, 7, and 1-hydroxyl groups with tert-butyldimethylsilyl chloride, triethy
METHODS AND COMPOSITIONS FOR CONVERTING TAXANE AMIDES TO PACLITAXEL OR OTHER TAXANES
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Page 7, (2008/06/13)
The invention relates to methods and compositions for converting taxane amides to paclitaxel or other taxanes. In one alternative embodiment, the present invention comprises; (i) selectively protecting at least one OH group of a taxane amide; (ii) contacting the taxane amide with a transition metal compound to reduce the amide; (iii) contacting the reduced amide with an agent capable of substantially removing the transition metal; (iv) contacting the reduced amide with a hydrolyzing amount of acid to form a taxane amine salt in solution; (v) adding a sufficient amount of solvent to solidify the amine salt; and (vi) converting the taxane amine salt into paclitaxel or other taxanes.
