15309-69-0

Basic information

• Product Name: Benzenesulfonamide, 4-methyl-N-4-pyridinyl-
• Synonyms: N-[4]pyridyl-toluene-4-sulfonamide;N-(4-pyridyl)-p-toluenesulfonamide;N-tosyl-4-aminopyridine;N-pyridin-4-yl-toluene-4-sulfonamide;N-[4]Pyridyl-toluol-4-sulfonamid;N-pyrid-4-yl-p-toluenesulfonamide
• CAS NO: 15309-69-0
• Molecular Formula: C12H12N2O2S
• Molecular Weight: 248.305
• Mol File: 15309-69-0.mol

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-methyl-N-4-pyridinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-methyl-N-4-pyridinyl-(15309-69-0)
• EPA Substance Registry System: Benzenesulfonamide, 4-methyl-N-4-pyridinyl-(15309-69-0)

Safety Data

• Hazardous Substances Data: 15309-69-0(Hazardous Substances Data)

Upstream product

• 504-24-5 4-aminopyridine 
• 98-59-9 p-toluenesulfonyl chloride 
• 514195-46-1 4-bis(p-tolylsulfonyl)aminopyridine 
• 1153-45-3 4-nitrophenyl 4-methylbenzenesulfonate 

Downstream Products

• 514195-42-7 4-pyridyl(tosyl)(2-quinolyl)amine 
• 514195-46-1 4-bis(p-tolylsulfonyl)aminopyridine 
• 504-24-5 4-aminopyridine 
• 15309-72-5 N-(1-methyl-1H-pyridin-4-ylidene)-p-toluenesulfonamide 

Relevant articles and documents

Reductive acylamination of pyridine N-oxide with aminopyridines and their N-p-tolylsulfonyl derivatives

Pyridine N-oxide reacts with 2- and 3-aminopyridines and their N-p-tolylsulfonyl derivatives in alkaline medium in the presence of p-toluenesulfonyl chloride to give N-p-tolylsulfonyl-2,2′- and 2,3′-dipyridylamines, respectively, as a result of reductive acylamination. In the reactions with 4-aminopyridine and 4-p-tolylsulfonyl- aminopyridine, their N-p-tolylsulfonyl- and N,N-bis(p-tolylsulfonyl) derivatives are formed, while reductive acylamination does not occur. 2005 Pleiades Publishing, Inc.

Reductive amination of quinoline N-oxide with aminopyridines and their N-tozyl derivatives

In reaction of quinoline N-oxide with 2-aminopyridine in the presence of tosyl chloride the substrate undergoes reductive amination into 2-pyridyl(2-quinolyl)amine, and with 3- and 4-aminopyridines reductive tosylamination occurs to furnish N-tosyl derivatives of the corresponding 3- and 4-pyridyl(2-quinolyl)amines. N-tosyl derivatives of aminopyridines also react along reductive tosylamination pathway.

Nucleophilic Substitution at the Tetracoordinated Sulfur. V. Reactivity of Amines and Azole Anions in Respect to Aryl 4-Tosylates in 80% Aqueous Dimethyl Sulfoxide

Acid dissociation constants of ammonium cations, imidazoles and phenols as well as the rates of aminolysis of p-toluenesulfonic esters 4-CH3C6H4SO2OC6H 4R in 80% aqueous DMSO at 25°C are measured. The angular coefficients of onsted plots in respect to attacking electrophiles and leaving group are close to those obtained earlier in protic media, indicating the similarity of the structure of transition states.