15311-09-8Relevant articles and documents
Rapid synthesis of 2,5-disubtituted 1,3,4-thiadiazoles under microwave irradiation
Lebrini, Mounim,Bentiss, Fouad,Lagrenee, Michel
, p. 991 - 994 (2007/10/03)
The one pot, three-components condensation of aromatic aldehydes, hydrazine and sulfur in ethanol under microwave irradiation provided symmetrically 3,5-disubstituted 1,3,4-thiadiazoles in high yields and good purity. This reaction must be conducted under pressure of hydrogen sulfide produced in-situ. The structure of the compounds was confirmed by 1H, 13C NMR, MS and elemental analysis.