153136-98-2

Basic information

• Product Name: 4-acetyl-1-benzoyl-3-methyl-1H-pyrazole
• Synonyms: 4-acetyl-1-benzoyl-3-methyl-1H-pyrazole
• CAS NO: 153136-98-2
• Molecular Weight: 228.25
• Mol File: 153136-98-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-acetyl-1-benzoyl-3-methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetyl-1-benzoyl-3-methyl-1H-pyrazole(153136-98-2)
• EPA Substance Registry System: 4-acetyl-1-benzoyl-3-methyl-1H-pyrazole(153136-98-2)

Safety Data

• Hazardous Substances Data: 153136-98-2(Hazardous Substances Data)

Upstream product

• 123-54-6 acetylacetone 
• 33884-41-2 ethoxylideneacetylacetone 
• 613-94-5 benzoic acid hydrazide 
• 1125402-40-5 4-acetyl-1-benzoyl-5-methyl-1H-pyrazole 
• 71043-35-1 3-methoxymethylenepentane-2,4-dione 

Downstream Products

• 105224-04-2 1-(3-methyl-1H-pyrazol-4-yl)ethanone 
• 787-84-8 N'-benzoylbenzohydrazide 
• 532-96-7 N-benzoyl-N'-phenylhydrazine 
• 495-18-1 Benzohydroxamic acid 

Relevant articles and documents

N → N acyl group migration in N-acylpyrazoles: Isomerization of 1,4-diacyl-5-methyl-1H-pyrazoles to 1,4-diacyl-3-methyl-1H-pyrazoles

1,4-Diacyl-5-methyl-1H-pyrazoles on heating in toluene undergo isomerization to 1,4-diacyl-3-methyl-1H-pyrazoles via intermolecular N → N acyl group migration. 1,4,5-Trisubstituted pyrazoles obtained by reaction of 2-ethoxymethylidene derivatives of 1,3-diketones with 1,3-benzothiazol-2-ylhydrazine or phenylhydrazine failed to isomerize to 1,3,4-trisubstituted pyrazoles.

Reaction of 3-Benzylidene-2,4-pentanedione and 3-Methoxymethylene-2,4-pentanedione with Aroylhydrazines

Aroylhydrazines 2 reacted with 3-benzylidene-2,4-pentanedione (1) to give 1-aroyl-3,5-dimethyl-1H-pyrazoles 5 and benzaldehyde aroylhydrazones 6. From the reaction of 3-methoxymethylene-2,4-pentanedione (7) with aroylhydrazines 2 the unknown N-aroyl-4-acetyl-1H-pyrazoles 9 were exclusively isolated in good yields.