153139-56-1Relevant articles and documents
Preparation method of ondansetron impurity A
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Paragraph 0021; 0022; 0023; 0024, (2019/01/08)
The invention discloses a preparation method of an ondansetron impurity A. The method comprises the following steps of firstly weighing ondansetron raw materials and a proper amount of aluminum chloride; adding a hydrogen peroxide water solution for dissolution to prepare the ondansetron solution, wherein the mass percentage of hydrogen peroxide in the hydrogen peroxide water solution is 12 percent; transferring the solution to a reaction kettle with a polytetrafluoroethylene inner liner; after the sealing, putting the reaction kettle into a baking oven for reaction for 8h at 140 DEG C; afterthe reaction is completed, cooling the materials into a room temperature; performing extraction by ethyl acetate; collecting the ethyl acetate part; performing concentration drying to obtain a hydrothermal reaction extract; then, performing separation and purification on the hydrothermal reaction extracts by an HSCCC method to obtain an impurity A. The method provided by the invention has the advantages that firstly through hydrothermal reaction, the ondansetron is degraded to obtain impurities A and D; the water is used as a medium; economical and environment-friendly effects are achieved; then, through HSCCC one step, the impurities A and D can be respectively obtained through separation and purification; the purity is 98 percent or higher.