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153144-01-5

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153144-01-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 153144-01-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,1,4 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 153144-01:
(8*1)+(7*5)+(6*3)+(5*1)+(4*4)+(3*4)+(2*0)+(1*1)=95
95 % 10 = 5
So 153144-01-5 is a valid CAS Registry Number.

153144-01-5Downstream Products

153144-01-5Relevant articles and documents

Effects of [(N-alkyl-1,3-dihydro-1-oxoisoindolin-5-yl)oxy]alkanoic acids on chloride transport in primary astroglial cultures

Waller,Wyrick,Park,Kemp,Smith

, p. 571 - 576 (2007/10/02)

It has been demonstrated that agents which inhibit chloride influx and, therefore, lower intracellular chloride levels in the astrocyte, a major cell type in the cerebral gray matter, inhibit astrocytic swelling in vitro and in vivo. Herein, we report additional examples of a series of [(N-alkyl-1,3- dihydro-1-oxoisoindolin-5-yl)oxy]alkanoic acids and their effects upon ion transport in primary rat astrocyte cultures. The 4-chloro-substituted 1- oxoisoindolines demonstrated superior astrocytic chloride influx inhibitory activity as compared to the 6-chloro and non-chlorinated analogs. The four- carbon acid side chain derivatives were more active than the three- and two- carbon analogs. The pharmacological profile of these compounds was examined with respect to inhibition of the Cl--Cl-/Cl--HCO3- anion exchanger and Na+-K+-2Cl cotransport mechanisms in glia, and the compounds were found to exhibit a similar profile to that of furosemide by inhibiting both transporters.

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