1531618-68-4Relevant academic research and scientific papers
Cytotoxic dihydrothiophene-condensed chromones from the marine-derived fungus penicillium oxalicum
Sun, Yu-Lin,Bao, Jie,Liu, Kai-Sheng,Zhang, Xiao-Yong,He, Fei,Wang, Yi-Fei,Nong, Xu-Hua,Qi, Shu-Hua
, p. 1474 - 1479 (2013)
Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus, Penicillium oxalicum. The structures of 1-3 and acetylated derivatives of 1 (4-7) were elucidated on the basis of spectroscopic methods and chemical reactions. The absolute configuration of 1 and 2 were established by using the modified Mosher ester method and circular dichroism data of an in situ formed [Rh2(OCOCF3)4] and [Mo2(OAc)4] complex. (R)-MTPA ester of 1 showed cytotoxicity against A375, SW-620, and HeLa carcinoma cell lines with IC 50 values of 8.9, 7.8, and 18.4 M, respectively. Compound 1 displayed cytotoxicity against A375 and SW-620 cell lines with IC50 values of 11.7 and 22.6 M, respectively. The structure-biological activity relationship of 1 was discussed. Georg Thieme Verlag KG Stuttgart.
A kind of chromone compounds and method for preparing the same and in the preparation of anti-tumor drug in the application of the enzyme inhibitor
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Paragraph 0079-0081, (2016/10/31)
The invention discloses a chromones compound, a preparing method thereof and chromones compound application in preparing antineoplastic and enzyme inhibitor medicines. The sulfur-containing chromones compound shown in a formula (I) is strong in effect of inhibiting the growth of lung adenocarcinoma cells or histocyte lymphoma cells or leukemia cells or gastric carcinoma cells or acute lymphoblastic leukemia cells or acute myeloblastic leukemia cells or hepatoma carcinoma cells. The chromones compound inhibits JAK3, AuroraA and ABL. The chromones compound has good application prospects in preparing the antineoplastic and the enzyme inhibitor medicines.
