1531629-10-3Relevant academic research and scientific papers
Nickel-Catalyzed Direct Amination of Arenes with Alkylamines
Yan, Qiangqiang,Chen, Zhengkai,Yu, Wenlong,Yin, Hong,Liu, Zhanxiang,Zhang, Yuhong
, p. 2482 - 2485 (2015)
(Figure Presented) The efficient nickel-catalyzed direct amination of arenes with simple alkylamines has been achieved with the assistance of a bidentate directing group through sp2 C-H bond functionalization. Preliminary mechanistic investigations indicate that the reaction probably proceeds through a NiI/NiIII catalytic pathway.
Synthesis of anthranilic acid derivatives through iron-catalyzed ortho amination of aromatic carboxamides with N-chloroamines
Matsubara, Tatsuaki,Asako, Sobi,Ilies, Laurean,Nakamura, Eiichi
supporting information, p. 646 - 649 (2014/02/14)
Arenes possessing an 8-quinolinylamide group as a directing group are ortho aminated with N-chloroamines and N-benzoyloxyamines in the presence of an iron/diphosphine catalyst and an organometallic base to produce anthranilic acid derivatives in high yield. The reaction proceeds via iron-catalyzed C-H activation, followed by the reaction of the resulting iron intermediate with N-chloroamine. The choice of the directing group and diphosphine ligand is crucial for obtaining the anthranilic acid derivative with high yield and product selectivity.
