153179-99-8

Upstream product

• 766-38-1 mucobromic acid 
• 2216-51-5 (-)-menthol 

Downstream Products

• 1172580-91-4 C₂₂H₂₅BrN₂O₄S₂ 
• 1172580-93-6 C₂₂H₂₄BrN₃O₅S₂ 
• 1172580-92-5 C₂₂H₂₅BrN₂O₄S₂ 
• 1172580-95-8 C₂₀H₂₃BrN₂O₄S₂ 
• 1172580-89-0 C₂₂H₂₅BrN₂O₃S₂ 
• 1172580-90-3 C₂₂H₂₄BrClN₂O₃S₂ 
• 1172580-96-9 C₂₁H₂₄BrN₃O₃S₂ 
• 1172580-97-0 C₂₁H₂₄BrN₃O₃S₂ 
• 1172580-94-7 C₂₃H₂₇BrN₂O₄S₂ 
• 1361130-61-1 (5S)-3-bromo-4-(dipropylamino)-5-menthyloxy-2(5H)-furanone 
• 1361130-59-7 (5S)-3-bromo-4-(diethylamino)-5-menthyloxy-2(5H)-furanone 
• 1361130-63-3 (5S)-3-bromo-4-(diisopropylamino)-5-menthyloxy-2(5H)-furanone 
• 1416444-36-4 (S)-2-((S)-4-bromo-2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-5-oxo-2,5-dihydrofuran-3-ylamino)pentanedioic acid 
• 1416444-45-5 (S)-diprop-2-ynyl 2-((S)-4-bromo-2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-5-oxo-2,5-dihydrofuran-3-ylamino)succinate 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel artemisone-piperazine-tetronamide hybrids

For the first time, six novel artemisone-piperazine-tetronamide hybrids (12a-f) were efficiently synthesised from dihydroartemisinin (DHA) and investigated for their in vitro cytotoxicity against some human cancer cells and benign cells. All the targets s

Synthesis and biological activities of dithiocarbamates containing 2(5H)-furanone-piperazine

A series of new dithiocarbamates containing a 2(5H)-furanone-piperazine group was synthesized. These compounds show good in vitro cytoxic activity. Among them, compound 6c exhibits the best inhibitory activity against HeLa cell lines with an IC50 of 0.06 ± 0.01 μM for 72 h, and it has good inhibitory activity against SMMC-7721 cell lines with an IC50 of 0.006 ± 0.04 μM for 72 h, but the toxicity was lower against LO2 cell lines with an IC50 of 45.76 ± 0.01 μM. The result showed that compound 6c is far more cytoxic towards cancer cell lines than towards benign cell lines compared with cytosine arabinoside (ARA) in vitro.

Design and synthesis of 2(5H)-furanone liquid-crystal compounds based on natural molecules and biphenyl derivatives

Starting from natural molecules, for example l-menthol and amino acids, a series of 2(5H)-furanone liquid-crystal compounds were designed, and synthesized by esterification of N-[5-menthoxy-2(5H)-furanonyl] amino acids with biphenyl-4-ol or biphenyl-4,4′-diol in the presence of dehydrating agents. The structures of all the novel compounds were confirmed by FTIR, 1H NMR, and mass spectroscopy, and by elemental analysis. The liquid-crystal properties of the target compounds were characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), and polarization optical microscopy (POM). The DSC and XRD results showed that some compounds containing short alkyl chains or with the phenyl far from the amino in the amino acid unit formed a mesomorphic phase. Products obtained from biphenyl-4,4′-diol were more likely to form a mesomorphic phase. However, POM revealed no optical texture. These investigations provide, for the first time, a basis for application of 2(5H)-furanones in liquid crystals by combination of different functional units, including biphenyl, l-menthol, and amino acids.

Synthesis of new chiral 2,5-disubstituted 1,3,4-thiadiazoles possessing γ-butenolide moiety and preliminary evaluation of in vitro anticancer activity

A new series of chiral 1,3,4-thiadiazoles derivatives possessing γ-substituted butenolide moiety were synthesized and evaluated for in vitro anticancer properties. All the compounds showed good anticancer activities against Hela cell lines. Of all the studied compounds, compound 9e exhibited the best inhibitory activity with an IC50 of 0.9 μM. After being treated with 0.1 μg/mL compound 9e for 24 h, the growth inhibition rate of Hela cell lines was 59.2%.