153181-66-9Relevant academic research and scientific papers
Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: Synthesis, structure - Activity relationships, and X-ray crystal structure studies
Jadhav, Prabhakar K.,Woerner, Francis J.,Lam, Patrick Y. S.,Nicholas Hodge,Eyermann, Charles J.,Man, Hon-Wah,Daneker, Wayne F.,Bacheler, Lee T.,Rayner, Marlene M.,Meek, James L.,Erickson-Viitanen, Susan,Jackson, David A.,Calabrese, Joseph C.,Schadt, Margaret,Chang, Chong-Hwan
, p. 1446 - 1455 (2007/10/03)
Comparison of the high-resolution X-ray structures of the native HIV-1 protease and its complexes with the inhibitors suggested that the enzyme flaps are flexible. The movement at the tip of the flaps could be as large as 7 A. On the basis of this observa
