153233-36-4

Usage

InChI:InChI=1/C12H10F3NO2/c13-12(14,15)9(5-11(17)18)8-6-16-10-4-2-1-3-7(8)10/h1-4,6,9,16H,5H2,(H,17,18)

Upstream product

• 120-72-9 indole 
• 1275517-81-1 diethyl (R)-2-(2,2,2-trifluoro-1-(1H-indol-3-yl)ethyl)malonate 
• 151636-96-3 (R)-ethyl 4,4,4-trifluoro-3-(1H-indol-3-yl)butanoate 
• 153233-39-7 diethyl 1-(indol-3-yl)-2,2,2-trifluoroethylmalonate 
• 116757-85-8 2,2,2-trifluoro-1-(indol-3-yl)ethanol 

Downstream Products

• 1275518-78-9 (1S,4S)-4-(trifluoromethyl)-2,3,4,9-tetrahydro-1-phenyl-1H-pyrido[3,4-b]indole 

Relevant academic research and scientific papers

(S)-(+)-4,4,4-Trifluoro-3-(indole-3-)butyric acid, a novel fluorinated plant growth regulator

Racemic 4,4,4-trifluoro-3-(indole-3-)butyric acid (TFIBA) has been synthesized and shown to inhibit Avena coleoptile elongation. (S)-(+)-TFIBA, which was prepared by an enzymatic method and markedly promotes root growth of Chinese cabbage, lettuce and rice plants, is a novel fluorinated plant growth regulator. Activity of the (S)-(+)-enantiomer of TFIBA was 10-fold greater than that of the (R)-(-)-enantiomer in the first two plant species and 5-fold greater in rice.

Catalytic asymmetric hydrogenation of α-CF3- or β-CF3-Substituted acrylic acids using Rhodium(I) complexes with a combination of chiral and achiral ligands

Only the mixture works! Acrylic acid derivatives with CF3 substituents in α or β position were efficiently hydrogenated in the presence of a RhI complex with a chiral secondary phosphine oxide (SPO; see scheme) and an achiral Ph3P as ligands. The corresponding propanoic acid derivatives were obtained with generally high conversion (>99 %) and high enantioselectivity (92->99 %). Copyright

Enantioselective friedel-crafts alkylation of indoles with trifluoroethylidene malonates by copper-bis(oxazoline) complexes: Construction of trifluoromethyl-substituted stereogenic tertiary carbon center

An enantioselective alkylation of indoles with trifluoroethylidene malonates catalyzed by copper(II)-bis (oxazoline) complexes has been developed. The expected adducts with a stereogenic tertiary carbon center bearing a trifluoromethyl group were obtained

An electrochemical approach for the synthesis of perfluoroalkylated purine and indole analogues of plant growth regulators

In an effort to prepare new fluorine-containing molecules as analogues of Plant Growth Regulators (PGRs), the indirect electrochemical reduction, by means of an aromatic anion mediator, of perfluoroalkyl halides in the presence of purine and indolyl anion