15325-57-2Relevant academic research and scientific papers
Silver-catalyzed regioselective carbomagnesiation of alkynes with alkyl halides and Grignard reagents
Kambe, Nobuaki,Moriwaki, Yuusuke,Fujii, Yuuki,Iwasaki, Takanori,Terao, Jun
supporting information; experimental part, p. 4656 - 4659 (2011/10/18)
A silver-catalyzed carbomagnesiation of alkynes with alkyl halides and Grignard reagents afforded alkenyl Grignard reagents regioselectively, where the alkyl group of the alkyl halide, but not that of the Grignard reagent, was introduced into the alkyne.
Iron-catalyzed alkylation of alkenyl grignard reagents
Cahiez, Gerard,Duplais, Christophe,Moyeux, Alban
, p. 3253 - 3254 (2008/02/12)
The first iron-catalyzed cross-coupling reaction between alkenyl Grignard reagents and n- or s-alkyl bromides is described. The reaction is stereoselective and takes place in the presence of 5 mol % of [Fe(acac) 3MEDA/HMTA] (1:2:1) under very mild conditions (THF, 0°C, 45 min).
Zinc metal-promoted stereoselective olefination of aldehydes and ketones with gem-dichloro compounds in the presence of chlorotrimethylsilane
Ishino, Yoshio,Mihara, Masatoshi,Nishihama, Shintaro,Nishiguchi, Ikuzou
, p. 2669 - 2672 (2007/10/03)
A combination of zinc metal and a catalytic amount of chlorotrimethylsilane has been found to promote the transformation of various aldehydes and ketones with gem-dichloro compounds, such as benzylidene dichloride (1a) and methyl dichloroacetate (1b), to the corresponding cross- coupling products, such as substituted styrene 3 and methyl acrylates 4 derivatives, under mild reaction conditions in THF. The E-isomer of the corresponding alkenes was obtained stereoselectively in good-to-excellent yields. The reaction serves as a very convenient one-pot procedure.
