153254-97-8Relevant articles and documents
Environment-friendly method for synthesizing propenyl ketone compound
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Paragraph 0019; 0028, (2019/01/04)
The invention discloses an environment-friendly method for synthesizing a propenyl ketone compound. The method comprises the following steps: subjecting an aldehyde compound and allyl bromide to a Barbier reaction in the presence of metal powder, so as to obtain an allyl alcohol compound; and subjecting the allyl alcohol compound to a structural isomerization reaction in the presence of a catalyst, thereby obtaining the propenyl ketone compound. The method disclosed by the invention has the advantages of short synthesis route, mild reaction conditions, simplicity in operation, readily available raw materials, and the like and has relatively high academic research value and market economy significance.
Preparation of some heterocyclic enones and ynones by isomerisation of the propargylic alcohols
Erenler, Ramazan,Uno, Masaharu,Goud, Thirumani Venkateshwar,Biellmanna, Jean-Francois
experimental part, p. 459 - 464 (2010/01/16)
The propargylic alcohols were synthesised by treatment of aldehydes with substituted acetylenes. The conversion of propargylic alcohols to propynones and propenones takes place with pyridine hydrochloride in methanol at room temperature. In presence of pyridinium triflate and p-toluenesulfonate the propynone was the only product isolated in the isomerisation of alcohol. The silylated propenone undergoes with cyclopentadiene a Diels-Alder cycloaddition to give ketone whose skeleton is related to that of quinine.
The anion of 4-dimethoxymethylpyridine. A convenient synthesis of some 4-pyridyl ketones
Sheldrake
, p. 1967 - 1971 (2007/10/02)
n-Butyllithium at -78°C abstracts the methine proton from 4-dimethoxymethylpyridine. The anion reacts efficiently with electrophiles. Simple ketal products can be readily hydrolysed to 4-pyridyl ketones.