153276-22-3Relevant academic research and scientific papers
Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.
Andres, J Ignacio,Alonso, Jose M,Diaz, Adolfo,Fernandez, Javier,Iturrino, Laura,Martinez, Pedro,Matesanz, Encarna,Freyne, Eddy J,Deroose, Frederik,Boeckx, Gustaaf,Petit, Davy,Diels, Gaston,Megens, Anton,Somers, Marijke,Van Wauwe, Jean,Stoppie, Paul,Cools, Marina,De Clerck, Fred,Peeters, Danielle,de Chaffoy, Didier
, p. 653 - 658 (2007/10/03)
This communication describes the synthesis and in vitro PDE4 inhibitory activity of a novel series of imidazol-2-one and 2-cyanoiminoimidazole derivatives. The compounds described were also tested in in vivo models to evaluate their anti-inflammatory activity after topical administration as well as their gastro-intestinal side effects. Several compounds proved to be potent PDE4 inhibitors and some 2-cyanoiminoimidazoles showed less pronounced gastro-intestinal side effects than reference compounds but maintained anti-inflammatory activity after topical administration.
Compounds useful for treating allergic or inflammatory diseases
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, (2008/06/13)
Novel cyclohexanes of Formulas (I) and (II) STR1 are described herein. They inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase V.
