153305-67-0

Usage

Chemical Properties

White to off-white crystalline powder

Upstream product

• 1342819-36-6 bis(4-methylphenyl)bromophosphine 
• 74866-28-7 2,2'-dibromo-1,1'-binaphthyl 
• 141807-44-5 (+/-)-2,2'-bis(trifluoromethanesulfonyloxy)-1,1-binaphthyl 

Downstream Products

• 577712-50-6 (4R,9aR)-6-benzyloxy-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester 
• 100165-87-5 (R)-(+)-2,2'-bis(di-p-tolylphosphinyl)-1,1'-binaphthyl 
• 100165-87-5 (S)-[1,1'-binaphthalene]-2,2'-diylbis(di-p-tolylphosphine oxide) 
• 112065-78-8 diacetato[(S)-(-)-2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl]ruthenium(II) 
• 352230-33-2 [Ag[C₂₀H₁₂(P(C₆H₅)2)2]CH₃COO] 
• 352230-34-3 [Ag[C₂₀H₁₂(P(C₆H₄CH₃)2)2]CH₃COO] 
• 352232-75-8 [Ag₂[C₂₀H₁₂(P(C₆H₄CH₃)2)2](CH₃COO)2] 
• 210693-89-3 [(S)-Tol-BINAP]Pd(o-C₆H₄CN)Br 
• 888955-58-6 hydrido(acetato)[(S)-2,2'-bis(di-4-tolylphosphino)-1,1'-binaphthyl]chloroiridium(III) 
• 112065-78-8 Δ-Ru(OOCCH3)2((S)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) 
• 112065-78-8 diacetato[(R)-(+)-2,2-bis(di-p-tolylphosphono)-1,1′?binaphthyl]ruthenium(II) 

Relevant academic research and scientific papers

NOVEL RUTHENIUM COMPLEX AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND USING SAME AS CATALYST

The present invention provides: a novel ruthenium complex which has excellent catalytic activity with respect to reactivity in the reduction of a multiple bond, in particular, in the asymmetric reduction of a carbonyl compound, enantioselectivity, etc.; a catalyst which comprises the ruthenium complex; and a process for producing optically active compound, in particular, an optically active alcohol compound, using the catalyst. The ruthenium complex has a ruthenacyclic structure. The catalyst is a catalyst for asymmetric reduction which comprises the ruthenium complex.

Improved syntheses of phosphine ligands by direct coupling of diarylbromophosphine with organometallic reagents

Br versus Cl: It is found that the use of diarylbromophosphines instead of diarylchlorophosphines is crucial for their direct coupling with binaphthylmagnesium bromide or BINOL triflate. This finding has led to an improved preparation of both electron-deficient BINAP-type phosphine ligands and several important Buchwald's ligands. Copyright

Ruthenium-I0D0-optically active phosphine complex

This invention is concerned with a ruthenium-iodo-optically active bidentate phosphine complex of the formula (I):[Ru-(I)q-(T1)n(SOL)r(L)]m(T2)p(I)s(I)wherein T1 represents a carboxylic acid anion, SOL represents a polar solvent, L represents an optically active bidentate phosphine ligand, T2 represents an anion different from halogen atom anions and carboxylic acid anions, n denotes 0 or 1, r denotes 0, 3 or 4, m denotes 1 or 2, q denotes 0 or 1, or where m is 2, q may represent 1 or 1.5, p denotes 0 or 1, and s denotes 0, 1 or 2 is prepared. Said phosphine complex is usefull as an efficient catalyst for asymmetrically hydrogenating 4-methylene-2-oxetanone into optically active 4-methyl-2-oxetanone.

Process for producing optically active benzhydrol compounds

A process for producing a benzhydrol compound (II) which comprises hydrogenating a benzophenone compound (I) in the presence of a hydrogenation catalyst consisting of a transition metal complex, a base and an optically active diamine compound: STR1 wherein R1 to R10 each represents H, OH, C1-4 alkyl, C1-4 alkoxy, C1-4 alkanoyl, etc., R2 and R3, and R8 and R9 may form --CH=CH--CH=CH--, or any two of R1 to R9 adjacent to each other may be bonded to thereby form --OCH2 O-- or --(CH2)3 --. By using this process, optically active benzhydrol compounds which have a high purity and are useful as, for example, intermediates in the synthesis of drugs can be produced by simple procedures.

N-substituted-7-amino-5-hydroxy-3-oxoheptanoic acid derivatives and method for producing the same

Compounds represented by the following general structural formula (1) and methods for producing the compounds: STR1 R1 represents a group such as benzyloxycarbonyl, R2 represents a lower alkyl group, R3 represents a hydrogen atom or a protecting group, each of M1 and M2 represents a metal atom, and n represents the atomic valence of M1. Intermediates for HMG-CoA reductase inhibitors can be prepared safely and easily from these compounds.

Process for preparing an optically active amine

A novel process for preparing an optically active amine by asymmetric hydrogenation of an imine compound, such as an imine compound prepared by condensing benzylamine and acetophenone, in the presence of a catalytic amount of an iridium-optically active phosphine complex and benzylamine or a benzylamine derivative. The present invention provides an optically active amine of high optical purity.

Process for preparing optically active 4-methyl-2-oxetanone

A process for preparing optically active 4-methyl-2-oxetanone which comprises asymmetrically hydrogenating 4-methylene-2-oxetanone in the presence of a ruthenium-optically active phosphine complex. Optically active 4-methyl-2-oxetanone can easily and economically be obtained at high optical purity.

Process for preparing optically active 4-methyl-2-oxetanone

A process for preparing optically active 4-methyl-2-oxetanone which comprises asymmetrically hydrogenating 4-methylene-2-oxetanone in the presence of a ruthenium-optically active phosphine complex. Optically active 4-methyl-2-oxetanone can easily and economically be obtained at high optical purity.

Ruthenium-phosphine complex

A ruthenium-phosphine complex represented by the formula (I) wherein R--BINAP represents tertiary phosphine represented by the formula (II) STR1 R which is the same represents hydrogen, methyl or t-butyl, S represents tertiary amine, y represents 0 or 1, and when y is 0, x represents 2, z represents 4 and p represents 1, and when y is 1, x represents 1, z represents 1 and p represents 0.