15332-10-2

Usage

Uses

DFB is an allosteric potentiator of mGluR-5.

Biological Activity

Novel allosteric potentiator of the metabotropic glutamate receptor mGlu 5 . Devoid of agonist activity itself, but potentiates (3-6-fold) the action of agonists at mGlu 5 without any effect at other mGlu subtypes (EC 50 for potentiation = 2-5.3 μ M).

InChI:InChI=1/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+

Upstream product

• 456-48-4 3-Fluorobenzaldehyde 

Downstream Products

• 15332-20-4 3,3'-difluorostilbene 

Related news

Femtosecond tuning dynamics of organic amplifiers based on injection into DFB (cas 15332-10-2) resonators of slant gratings08/10/2019

We report regenerative amplification of femtosecond laser pulses locked by injection of supercontinuum spectrum into a distributed feedback (DFB) microcavity constructed by slant gratings. Destroying the symmetry of the DFB resonance modes about the normal injection, the slant grating not only e...detailed

An early fire gas sensor based on 2.33 μm DFB (cas 15332-10-2) laser08/09/2019

We report the development of a distribution feedback (DFB) laser sensor for high precision and high sensitivity detection of the early fire gas carbon monoxide (CO). This system relied on a continuous wave (CW), distributed feedback laser emitting at a wavelength of around 2.33 μm as excitation...detailed

A tunable dual-wavelength fiber ring-cavity laser based on semiconductor optical amplifier using two external-injected DFB (cas 15332-10-2) lasers08/08/2019

A tunable dual-wavelength fiber ring-cavity laser based on semiconductor optical amplifier (SOA) using two external-injected distributed feedback (DFB) lasers is proposed and experimentally demonstrated. When one of the injected DFB lasers operates at 25 °C and the other at 0 °C, a stable dual...detailed

Relevant academic research and scientific papers

Ruthenium(ii)-catalysed 1,2-selective hydroboration of aldazines

Herein, an efficient and simple catalytic method for the selective and partial reduction of aldazines using ruthenium catalyst [Ru(p-cymene)Cl2]2 (1) has been accomplished. Under mild conditions, aldazines undergo the addition of pinacolborane in the presence of a ruthenium catalyst, which delivered N-boryl-N-benzyl hydrazone products. Notably, the reaction is highly selective, and results in exclusive mono-hydroboration and desymmetrization of symmetrical aldazines. Mechanistic studies indicate the involvement of in situ formed intermediate [{(η6-p-cymene)RuCl}2(μ-H-μ-Cl)] (1a) in this selective hydroboration.

An expeditious synthetic approach towards the synthesis of Bis-Schiff bases (aldazines) using ultrasound

Aldazines (Bis-Schiff bases) 1-24 were synthesized using aromatic aldehydes (heterocyclic and benzaldehydes) and hydrazine hydrate under reflux using conventional heating and/or via ultrasound irradiation using BiCl3 as catalyst. Ultrasonication conditions with cat. BiCl3 proved to be an effective, environmentally friendly synthetic procedure. This methodology is robust in the presence of electron donating and electron withdrawing groups affording desired products with high yields (>95%) in just a couple of minutes vs. hours using conventional heating.

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5

We have identified a family of highly selective allosteric modulators of the group I metabotropic glutamate receptor subtype 5 (mGluR5). This family of closely related analogs exerts a spectrum of effects, ranging from positive to negative allosteric modu