1533422-47-7

Basic information

• Product Name: C₁₃H₁₆F₃NO₅S
• Synonyms: C₁₃H₁₆F₃NO₅S
• CAS NO: 1533422-47-7
• Molecular Weight: 355.335
• Mol File: 1533422-47-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₆F₃NO₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₆F₃NO₅S(1533422-47-7)
• EPA Substance Registry System: C₁₃H₁₆F₃NO₅S(1533422-47-7)

Safety Data

• Hazardous Substances Data: 1533422-47-7(Hazardous Substances Data)

Upstream product

• 1401094-66-3 methyl N-triflyl-L-homoalaninate 
• 171364-79-7 2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

Ligand-enabled cross-coupling of C(sp 3)-H bonds with arylboron reagents via Pd(II)/Pd(0) catalysis

There have been numerous developments in C-H activation reactions in the past decade. Attracted by the ability to functionalize molecules directly at ostensibly unreactive C-H bonds, chemists have discovered reaction conditions that enable reactions of C(sp 2)-H and C(sp 3)-H bonds with a variety of coupling partners. Despite these advances, the development of suitable ligands that enable catalytic C(sp 3)-H bond functionalization remains a significant challenge. Herein we report the discovery of a mono-N-protected amino acid ligand that enables Pd(II)-catalysed coupling of γ-C(sp 3)-H bonds in triflyl-protected amines with arylboron reagents. Remarkably, no background reaction was observed in the absence of ligand. A variety of amine substrates and arylboron reagents were cross-coupled using this method. Arylation of optically active substrates derived from amino acids also provides a potential route for preparing non-proteinogenic amino acids.