1533453-03-0Relevant articles and documents
Tandem Rh-catalysis: Decarboxylative β-keto acid and alkyne cross-coupling
Cruz, Faben A.,Chen, Zhiwei,Kurtoic, Sarah I.,Dong, Vy M.
, p. 5836 - 5839 (2016)
Herein, we describe a regioselective Rh-catalyzed decarboxylative cross-coupling of β-keto acids and alkynes to access branched γ,δ-unsaturated ketones. Rh-hydride catalysis enables the isomerization of an alkyne to generate a metal-allyl species that can undergo carbon-carbon bond formation. Ketones are generated under mild conditions, without the need for base or activated electrophiles.
Rhodium-catalyzed chemo- and regioselective decarboxylative addition of β-ketoacids to allenes: Efficient construction of tertiary and quaternary carbon centers
Li, Changkun,Breit, Bernhard
supporting information, p. 862 - 865 (2014/02/14)
A rhodium-catalyzed chemo- and regioselective intermolecular decarboxylative addition of β-ketoacids to terminal allenes is reported. Using a Rh(I)/DPPF system, tertiary and quaternary carbon centers were formed with exclusively branched selectivity under mild conditions. Preliminary mechanism studies support that the carbon-carbon bond formation precedes the decarboxylation and the reaction occurs in an outer-sphere mechanism.
