1533519-86-6

Basic information

• Product Name: N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide
• Synonyms: N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide;4-(3- mercapto -4H-1,2,4-triazol-4-yl)- 1-cycpropylnaphthalene;Lesinurad Impurity 33;3-(4-cyclopropylnaphthalen-1-yl)-1-formylaminothiourea
• CAS NO: 1533519-86-6
• Molecular Formula: C₁₅H₁₅N₃OS
• Molecular Weight: 285.3641
• Mol File: 1533519-86-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 456.9±38.0 °C(Predicted)
• Appearance: /
• Density: 1.375±0.06 g/cm3(Predicted)
• PKA: 8?+-.0.70(Predicted)
• CAS DataBase Reference: N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide(1533519-86-6)
• EPA Substance Registry System: N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide(1533519-86-6)

Safety Data

• Hazardous Substances Data: 1533519-86-6(Hazardous Substances Data)

Usage

General Description

N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide is a chemical compound that is a formylhydrazinecarbothioamide derivative with a cyclopropyl-naphthalene ring substitution. It is used in research and chemical studies as a reagent and intermediate in the synthesis of other organic compounds. This chemical may have potential applications in pharmaceutical research and drug development due to its structural attributes and reactivity. Its properties and potential uses in various fields make it an important chemical for further exploration and investigation.

Upstream product

• 878671-95-5 1-cyclopropylnaphthalene-4-yl isothiocyanate 
• 624-84-0 formic acid hydrazide 
• 2298-07-9 4-Bromo-1-naphthylamine 
• 1533519-91-3 tert-butyl 4-cyclopropylnaphthalen-1-ylcarbamate 
• 1533519-92-4 1-amino-4-cyclopropylnaphthalene hydrochloride 
• 1533519-87-7 1-amino-4-cyclopropylnaphthalene oxalate 
• 878671-93-3 1-cyclopropyl-4-nitronaphthalene 
• 25033-19-6 1-cyclopropyl-naphthalene 
• 90-11-9 1-Bromonaphthalene 
• 878671-94-4 1-amino-4-cyclopropylnaphthalene 

Downstream Products

• 878672-00-5 2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid 
• 1533519-84-4 4-(4-cyclopropylnaphthalen-1-yl)-4Η-1,2,4-triazole-3-thiol 
• 1533519-85-5 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-yl)thio)acetic acid methyl ester 
• 878672-00-5 (-)-2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid 
• 878672-00-5 (+)-2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid 

Relevant articles and documents

Lesinurad intermediate impurity dimer as well as preparation method and application thereof

The invention relates to a Lesinurad intermediate impurity dimer as well as a preparation method and application thereof, and belongs to the technical fields of drug synthesis and analysis. In order to solve the problem that an impurity in the synthesis process cannot be effectively identified, the invention provides the Lesinurad intermediate impurity dimer as well as the preparation method and application of the dimer. The preparation method of the dimer comprises the following steps: performing a reaction on 4-cyclopropyl-1-naphthyl isothiocyanate and formylhydrazine to obtain a compound containing the impurity dimer represented by a formula III shown in the description, and performing column chromatography separation to obtain the corresponding dimer or performing a reaction on 4-cyclopropyl-1-naphthyl isothiocyanate and hydrazine to obtain the impurity dimer. The impurity dimer provided by the invention can provide analysis and monitoring for the impurity in the synthesis processof an intermediate, effectively provide a reference substance of the impurity, facilitates improving the quality of the Lesinura intermediate and the product, and facilitates improving the product yield and production efficiency; and the process is simple and easy to operate.

THIO-1,2,4-TRIAZOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME

Provided is a process for preparing a compound shown as formula (I), comprising a step of contacting a compound shown as formula (II) or a salt thereof with a brominating agent, wherein R1is OR2 or NR3R4; R2 is C1-C6 alkyl or phenyl; each R3, R4 is independently H, C1-C6 alkyl or cycloalkyl, wherein C1-C6 alkyl, cycloalkyl, or phenyl is optionally further substituted by F, Cl, Br, CH3 or CF3. A process for preparing a compound shown as formula (II), a process for preparing a compound shown as formula (V), a process for preparing a compound shown as formula (III), and an intermediate compound as shown as formula (IIa) or formula (Ib) are also provided.