1533519-93-5 Usage
General Description
Lesinurad Impurity B is a chemical compound that is used as an impurity reference standard for lesinurad, which is a drug used for the treatment of gout. It is a crystalline solid with a molecular formula of C16H11ClN4O3S and a molecular weight of 374.8 g/mol. Lesinurad Impurity B is a potential impurity that may be present in lesinurad drug substance and needs to be monitored and controlled during the manufacturing process. It is important for analytical laboratories and pharmaceutical companies to have access to a certified reference material of Lesinurad Impurity B in order to accurately identify and quantify this impurity in lesinurad drug products.
Check Digit Verification of cas no
The CAS Registry Mumber 1533519-93-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,3,3,5,1 and 9 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1533519-93:
(9*1)+(8*5)+(7*3)+(6*3)+(5*5)+(4*1)+(3*9)+(2*9)+(1*3)=165
165 % 10 = 5
So 1533519-93-5 is a valid CAS Registry Number.
1533519-93-5Relevant articles and documents
Identification of an Unexpected Impurity in a New Improved Synthesis of Lesinurad
Halama, Ale?,Stach, Jan,Rádl, Stanislav,Benediktová, Kristyna
, p. 1861 - 1867 (2018)
An unexpected phenomenon concerning an otherwise common impurity of lesinurad has been observed in the context of synthetic process development. A new industrial process was designed as a chlorine-free process, but the critical chlorinated impurity 10 was surprisingly detected in the isolated product. Because of the structural similarity of the impurity and the product, no efficient separation of 10 by conventional methods (e.g., crystallization) was discovered. The formation of the impurity was explained by a chlorine impurity in a commercial brominating agent. This communication also describes control of the critical impurity.
