153391-41-4

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 153391-26-5 6-(4-fluorophenyl)-4-(methylthio)-2-oxo-2H-pyran-3-carbonitrile 

Downstream Products

• 1574531-99-9 (Z)-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)-3-(dimethylamino)acrylonitrile 

Relevant academic research and scientific papers

Photophysical and electrochemical studies of highly fluorescent pyrazole and imidazole containing heterocycles

Highly congested pyrazole and imidazole ring containing heterocycles were studied for their photophysical and electrochemical properties. TDDFT calculations of the molecules were carried out using B3LYP/G(d,p) level theory in DMF medium and the results we

A carbanion induced synthesis of highly congested pyrazole and imidazole containing heterocycles

An efficient approach to the synthesis of highly congested di, penta and hexacyclic pyrazoles as well as imidazole fragment containing novel heterocyclic molecule has been developed through a carbanion induced transformation of suitably functionalized 2H-

Synthesis of novel heterocyclic compounds: Routes to pyrazolyl 1,2,3-triazoles and their biological activity evaluation

A series of 5-aryl-3-cyanomethylpyrazoles have been synthesized by refluxing 6-aryl-3-cyano-4-methylthio-2H-pyran2-ones with hydrazine. The active methylene moiety of these pyrazoles has further been exploited to build 1,4-disubstituted 5-amino-1,2,3-tria

Synthesis of E- and Z-Pyrazolylacrylonitriles and their evaluation as novel antioxidants

A facile synthesis of (Z)- and (E)-2-(5-arylpyrazol-3-yl)-3-(pyrrol-2-yl)acrylonitriles and (Z)-2-(1,3-diarylpyrazol-5-yl)-3-(pyrrol-2-yl)acrylonitriles, and isomerisation of (Z)-2-(5-arylpyrazolyl)acrylonitriles to (E)-2-(5-arylpyrazolyl)acrylonitriles under basic conditions have been reported. (Z)-2-(1,3-Diarylpyrazolyl)acrylonitriles did not undergo isomerisation under the similar conditions. New compounds were identified on the basis of their spectral data (1H-, 13C-, 1H-1H COSY, NOESY, NOE, HMQC NMR, IR, UV and EI mass). The structures of one acrylonitrile and five of their precursor 6-arylpyran-2-ones and cyanomethylpyrazoles were confirmed by X-ray crystallographic studies. Effects of pyrazolylacrylonitriles and their precursors on rat liver-microsomal lipid peroxidation were evaluated in vitro with a view to establish structure-activity relationship and to identify a lead compound. Copyright (C) 1999 Elsevier Science Ltd.

Synthetic and mass spectral fragmentation studies on trisubstituted 2H-pyran-2-ones and comparative EIMS behaviour of biologically active 3,5-disubstituted pyrazoles and isoxazoles

Eight 3-cyano-4-thiomethyl-6-aryl-2H-pyran-2-ones 1-8 and three 3-cyano-4-(N,N-dimethy)amino-6-aryl-2H-pyran-2-ones 9-11 have been synthesised and their detailed mass fragmentation pattern alongwith the X-ray crystal structure of a novel pyrone 5 have been studied. In addition, a comparative EIMS behaviour of 3,5-disubstituted pyrazoles 16-23 and isoxazoles 12-15 is reported. The pyrazole derivative 23 has been found to possess strong anti-invasive activity against human breast carcinoma cells.

Ring transformation reaction: Part II - Reaction specificity of hydrazines towards 6-aryl-4-(methylthio)-2-oxo-2H-pyran-3-carbonitriles and corresponding 3-ethyl carboxylate

Reaction specificity of hydrazine hydrate, cyclohexyl- and phenyl-hydrazines towards 6- or 5,6-disubstituted-4-(methylthio)-2-oxo-2H-pyran-3-carbonitriles and the corresponding 3-ethyl carboxylate (1,8) has been studied.