153394-55-9

Upstream product

• 7732-18-5 water 
• 26961-27-3 2-amino-4,5-dimethoxybenzonitrile 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 6315-89-5 3,4-dimethoxyaniline 
• 881-70-9 3',4'-dimethoxyacetanilide 
• 189001-13-6 2-acetylamino-3',4,4'-5-tetramethoxybenzophenone 

Downstream Products

• 153394-63-9 2-chloromethyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazoline 
• 161493-22-7 4-(3,4-dimethoxyphenyl)-2-hydroxymethyl-6,7-dimethoxyquinoline-3-carboxylic acid lactone 
• 158146-85-1 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester 
• 158147-45-6 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-3-ethoxycarbonylquinoline-2-acetic acid ethyl ester 
• 161493-85-2 ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2(1H)-quinolone-3-carboxylate 
• 174524-25-5 3-acetyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-quinoline 
• 153394-50-4 2-chloromethyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinoline-3-carboxylic acid ethyl ester 
• 174524-28-8 3-chloro-2-chloromethyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinoline 
• 153394-76-4 ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-[(1-methylimidazol-2-yl)thiomethyl]quinoline-3-carboxylate 

Relevant academic research and scientific papers

Palladium-catalyzed direct addition of arylboronic acids to 2-aminobenzonitrile derivatives: Synthesis, biological evaluation and in silico analysis of 2-aminobenzophenones, 7-benzoyl-2-oxoindolines, and 7-benzoylindoles

A palladium-catalyzed direct addition of arylboronic acids to unprotected 2-aminobenzonitriles has been developed, leading to a wide range of 2-aminobenzophenones with moderate to excellent yields. The transformation has broad scope and high functional group tolerance. Moreover, 2-oxoindoline-7-carbonitrile and indole-7-carbonitrile were applicable to this process for the construction of 7-benzoyl-2-oxoindolines and 7-benzoylindoles, respectively. Among the compounds examined, compound 4e possessed the most potent anticancer activity against H446 and HGC-27 in vitro, with IC50 values of 0.02 μmol L-1 and 0.09 μmol L-1, respectively, while compound 4a showed the best potent anticancer activity against SGC-7901 with an IC50 value of 0.01 μmol L-1. Furthermore, we also performed in silico molecular docking calculations to investigate the interaction mode and binding affinity between the examined compounds and their tubulin target. This journal is

Process development of a disease-modifying antirheumatic drug, TAK-603, based on optimization of Friedel-Crafts reaction and selective substitution of a triazole ring

A practical method for the preparation of TAK-603, an antirheumatic drug, has been developed. As a result of optimizing the Friedel-Crafts reaction in the presence of SnCl4/POCl3, 2-aminobenzophenone skeleton, the key intermediate of

Process for the preparation of 2-amino-4,5,3',4'-tetramethoxybenzophenone

2-Amino-4,5,3',4'-tetramethoxybenzophenone of the formula: is prepared by mononitration of 3,3',4,4'-tetramethyoxybenzophenone using nitric acid in the presence of acetic acid, and subsequent reduction of the nitro group. The compound is an intermediate i