153409-52-0

Usage

Uses

Used in Pharmaceutical Industry:
1-Propanone, 2-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)is used as a pharmaceutical compound for its potential therapeutic properties. The presence of multiple hydroxyl groups may allow for interactions with various biological targets, making it a candidate for the development of new drugs.
Used in Chemical Synthesis:
1-Propanone, 2-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)can be used as a starting material or intermediate in the synthesis of other complex organic compounds. Its unique structure may be valuable in the creation of novel molecules with specific properties or applications.
Used in Research and Development:
Due to its unique structure, 1-Propanone, 2-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)may be utilized in research and development for studying various chemical reactions and mechanisms. It could also be used to investigate the effects of different functional groups on the properties and reactivity of organic compounds.

Upstream product

• 446-72-0 5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on 

Relevant academic research and scientific papers

Dietary Genistein Reduces Methylglyoxal and Advanced Glycation End Product Accumulation in Obese Mice Treated with High-Fat Diet

Our previous study has found that dietary genistein could ameliorate high-fat diet (HFD)-induced obesity and especially lower methylglyoxal (MGO) and advanced glycation end product (AGE) accumulation in healthy mice exposed to genistein and HFD. However, it is still unclear whether dietary genistein intervention has a similar beneficial effect in obese mice. In this study, the mice were induced with obesity after being fed a HFD for nine weeks before being administered with two doses of genistein, 0.1percent (G 0.1) and 0.2percent (G 0.2), in the HFD for additional 19 weeks. After 19 week treatment, genistein supplementation reduced body and liver weights, plasma and liver MGO levels, and kidney AGE levels in mice. Mechanistically, genistein upregulated the expressions of glyoxalase I and II and aldose reductase to detoxify MGO, and genistein and its microbial metabolites, dihydrogenistein and 6′-hydroxy-O-demethylangolensin, were able to trap endogenous MGO via formation of MGO conjugates. Taken together, our results provide novel insights into the antiobesity and antiglycation roles of dietary genistein in obese subjects.