1534365-63-3Relevant academic research and scientific papers
Elucidating hydroxylation and methylation steps tailoring piericidin a1 biosynthesis
Chen, Yaolong,Zhang, Wenjun,Zhu, Yiguang,Zhang, Qingbo,Tian, Xinpeng,Zhang, Si,Zhang, Changsheng
supporting information, p. 736 - 739 (2014/03/21)
The piericidin A1 (1) gene cluster was identified from the deep-sea derived Streptomyces sp. SCSIO 03032. Our in vivo and in vitro experiments verified PieE as a 4′-hydroxylase and PieB2 as a 4′-O-methyltransferase, allowing the elucidation of the post-PKS modification steps involved in 1 biosynthesis. In addition, the shunt metabolite piericidin E1 (7) was identified as a novel analogue featuring a C-2/C-3 epoxy ring.
