1534433-44-7Relevant academic research and scientific papers
Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp3)-H bonds with aryl halides
Li, Mingliang,Dong, Jiaxing,Huang, Xiaolei,Li, Kaizhi,Wu, Qian,Song, Feijie,You, Jingsong
supporting information, p. 3944 - 3946 (2014/04/03)
In this work, we have disclosed the nickel-catalyzed unactivated β-C(sp3)-H bond arylation of aliphatic acid derivatives with aryl iodides/bromides via bidentate chelation-assistance of an 8-aminoquinoline moiety. These preliminary results indi
Nickel-catalyzed direct arylation of C(sp3)-H bonds in aliphatic amides via bidentate-chelation assistance
Aihara, Yoshinori,Chatani, Naoto
, p. 898 - 901 (2014/02/14)
The Ni-catalyzed, direct arylation of C(sp3)-H (methyl and methylene) bonds in aliphatic amides containing an 8-aminoquinoline moiety as a bidentate directing group with aryl halides is described. Deuterium-labeling experiments indicate that the C-H bond cleavage step is fast and reversible. Various nickel complexes including both Ni(II) and Ni(0) show a high catalytic activity. The results of a series of mechanistic experiments indicate that the catalytic reaction does not proceed through a Ni(0)/Ni(II) catalytic cycle, but probably through a Ni(II)/Ni(IV) catalytic cycle.
