1534433-46-9

Upstream product

• 60433-00-3 methyl cycloheptanecarboxylate 
• 7362-77-8 C₁₀H₁₈O₂ 
• 35664-93-8 1-methyl-cycloheptanecarboxylic acid 
• 696-62-8 para-iodoanisole 
• 1534433-38-9 1-methyl-N-(quinolin-8-yl)cycloheptanecarboxamide 
• 35664-99-4 1-methylcycloheptanecarbonyl chloride 
• 1330681-27-0 (4-methoxyphenyl)(mesityl)iodonium trifluoromethanesulfonate 

Relevant academic research and scientific papers

Direct arylation of C(sp3)-H bonds in aliphatic amides with diaryliodonium salts in the presence of a nickel catalyst

The Ni(II)-catalyzed direct arylation of C(sp3)-H (methyl and methylene) bonds in aliphatic amides containing an 8-aminoquinoline moiety as the directing group with diaryliodonium salts as coupling electrophiles is described. A wide variety of functional groups are tolerated in the reaction. The reaction represents the first example of the Ni-catalyzed direct arylation of C(sp3)-H bonds with diaryliodonium salts. (Chemical Equation Presented).

Nickel-catalyzed direct arylation of C(sp3)-H bonds in aliphatic amides via bidentate-chelation assistance

The Ni-catalyzed, direct arylation of C(sp3)-H (methyl and methylene) bonds in aliphatic amides containing an 8-aminoquinoline moiety as a bidentate directing group with aryl halides is described. Deuterium-labeling experiments indicate that the C-H bond cleavage step is fast and reversible. Various nickel complexes including both Ni(II) and Ni(0) show a high catalytic activity. The results of a series of mechanistic experiments indicate that the catalytic reaction does not proceed through a Ni(0)/Ni(II) catalytic cycle, but probably through a Ni(II)/Ni(IV) catalytic cycle.