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153463-20-8

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153463-20-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 153463-20-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,4,6 and 3 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 153463-20:
(8*1)+(7*5)+(6*3)+(5*4)+(4*6)+(3*3)+(2*2)+(1*0)=118
118 % 10 = 8
So 153463-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C27H37F7O2/c1-15(5-4-10-25(28,26(29,30)31)27(32,33)34)20-14-21(36)22-18-7-6-16-13-17(35)8-11-23(16,2)19(18)9-12-24(20,22)3/h15-17,19-20,35H,4-14H2,1-3H3/t15-,16+,17+,19+,20-,23+,24-/m1/s1

153463-20-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S,5S,9R,10S,13R,17R)-3-hydroxy-10,13-dimethyl-17-[(2R)-6,7,7,7-tetrafluoro-6-(trifluoromethyl)heptan-2-yl]-1,2,3,4,5,6,7,9,11,12,16,17-dodecahydrocyclopenta[a]phenanthren-15-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:153463-20-8 SDS

153463-20-8Downstream Products

153463-20-8Relevant articles and documents

Inhibitors of sterol synthesis: Synthesis and spectral properties of derivatives of 3β-hydroxy-25,26,26,26,27,27,27-heptafluoro-5α-cholest-8(14)-en-15- one fluorinated at carbon 7 or carbon 9 and their effects on 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in cultured mammalian cells

Siddiqui, Abdul U.,Swaminathan, Shankar,Pinkerton, Frederick D.,Gerst, Nicolas,Wilson, William K.,Choi, Hyunah,Schroepfer Jr., George J.

, p. 59 - 75 (1994)

As part of a program to prepare Δ8(14)-15-ketosterols that cannot readily be metabolized to cholesterol or side-chain oxygenated species, we have prepared 3β-hydroxy-7α-fluoro-5α-cholest-8(14)-en-15-one (VII) and the 9α-hydroxy (IV), 9α-fluoro (VI) and 7α-fluoro (VIII) derivatives of 3β-hydroxy-25,26,26,26,27,27,27-heptafluoro-5α-cholest-8(14)-en-15- one (II). Sterol IV was prepared by oxidation of the Δ8,14 dienol ethyl ether of the 3β-acetate of II with m-chloroperbenzoic acid, followed by mild alkaline hydrolysis of the 3β-acetate derivative of IV. Treatment of IV with hydrogen fluoride-pyridine gave VI. The 7α-fluoro-15-ketosterols VII and VIII were synthesized by treating the 3β,15-bis-trimethylsilyl Δ7,14-dienol ether derivative of the appropriate Δ8(14)-15-ketosterol with N-fluoropyridinium triflate, followed by hydrolysis of residual trimethylsilyl ethers and purification by high-performance liquid chromatography. The combined results of 1H and 13C nuclear magnetic resonance (NMR) chemical shifts, 1H-1H coupling constants, 1H-19F long-range coupling constants and molecular modeling indicated that a 7α-fluoro, 9α-fluoro or 9α-hydroxy substituent has negligible effect on the conformation of the 15-ketosterols. 1H and 13C-NMR data are also given for Δ6,8(14)- and δ8(14),9(11)-15-ketosterols, synthetic byproducts that could not be detected readily in samples of the fluoro-15-ketosterols by chromatographic methods. Mass spectra of VI and of previously reported 9α-fluoro and 9α-hydroxy-Δ8(14)-15-ketosterols showed abundant M-62 or M-60 ions that appear to correspond to loss of ketene and HF or H2O. The 9α-hydroxy-F7-15-ketosterol IV, the 7α-fluoro-15-ketosterol VII and the 7α-fluoro-F7-15-ketosterol VIII were of equivalent potency to the parent 3β-hydroxy-5α-cholest-8(14)-en-15-one (I) in lowering the levels of 3- hydrox-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells. The 9α-fluoro-F7-15-ketosterol VI showed high potency but appeared to be slightly less active than I.

SIDE CHAIN DERIVATIZED 15-OXYGENATED STEROLS, METHODS OF USING THEM AND A PROCESS FOR PREPARING THEM

-

, (2008/06/13)

Pharmaceutical compositions are provided for lowering the activity of HMG-CoA reductase and/or lowering serum cholesterol, comprising an amount effective to lower the activity of HMG-CoA reductase and/or lower serum cholesterol of a side chain derivatized

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