153478-14-9Relevant articles and documents
Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors
Deng, Wuqing,Chen, Xiaojuan,Jiang, Kaili,Song, Xiaojuan,Huang, Minhao,Tu, Zheng-Chao,Zhang, Zhang,Lin, Xiaojing,Ortega, Raquel,Patterson, Adam V.,Smaill, Jeff B.,Ding, Ke,Chen, Suming,Chen, Yongheng,Lu, Xiaoyun
supporting information, p. 647 - 652 (2021/05/06)
Covalent kinase inhibitors are rapidly emerging as a class of therapeutics with clinical benefits. Herein we report a series of selective 2-aminopyrimidine-based fibroblast growth factor receptor 4 (FGFR4) inhibitors exploring different types of cysteine-
Nitrogen-containing fused ring compounds as well as preparation method and application thereof
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Paragraph 0181; 0182, (2019/05/16)
The invention discloses nitrogen-containing fused ring compounds as well as a preparation method and application thereof. The nitrogen-containing fused ring compounds have a structure represented by aformula (I) shown in the description, wherein each grou
Pyrimidopyridone compounds having antitumor activity as well as preparation method and application of pyrimidopyridone compounds
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Paragraph 0075-007, (2019/08/20)
The invention discloses pyrimidopyridone compounds having antitumor activity as well as a preparation method and application of the pyrimidopyridone compounds. The invention particularly discloses thedeuterated pyrimidopyridone compounds represented by a