1535-93-9Relevant academic research and scientific papers
Perfluorinated bronsted 'superacids': Powerful catalysts for the preparation of vitamin E
Netscher, Thomas,Bonrath, Werner,Haas, Alois,Hoppmann, Eike,Pauling, Horst
, p. 153 - 155 (2004)
The key-step in the industrial synthesis of (all-rac)-α-tocopherol (synthetic vitamin E) is the condensation reaction of trimethylhydroquinone with the C20 building block isophytol. For this Friedel-Crafts-type reaction, perfluorinated NH- and CH-acidic compounds (perfluoroalkyl(aryl) sulfonyl imides and methides) have been applied as excellent catalysts, preferably in biphasic solvent systems.
