1535192-71-2Relevant academic research and scientific papers
Exploiting protein symmetry to design light-controllable enzyme inhibitors
Reisinger, Bernd,Kuzmanovic, Natascha,Loeffler, Patrick,Merkl, Rainer,Koenig, Burkhard,Sterner, Reinhard
, (2014)
The activity of the metabolic branch-point enzyme PriA from Mycobacterium tuberculosis (mtPriA) can be controlled reversibly by light. Two-pronged inhibitors based on the dithienylethene scaffold were designed utilizing mtPriA's natural rotational symmetr
