153531-53-4Relevant academic research and scientific papers
Potent half-sandwich Ru(Ⅱ) N^N (aryl-BIAN) complexes: Lysosome-mediated apoptosis, in vitro and in vivo anticancer activities
Xu, Zhishan,Huang, Jie,Kong, Deliang,Yang, Yuliang,Guo, Lihua,Jia, Xianglei,Zhong, Genshen,Liu, Zhe
, (2020/09/02)
Herein a new series of organometallic half-sandwich Ru(Ⅱ) complexes bearing aryl-BIAN chelating ligands with various electron-withdrawing and electron-donating substituents have been developed as theranostic agents. All the complexes display much higher anti-proliferative potency than the clinical chemotherapeutic drug cisplatin towards seven cancer cell lines. The anti-proliferative efficacy of these complexes is correlated to their electron-withdrawing ability. Interestingly, complex Ru1 also potently suppresses cancer cell migration in vitro and effectively inhibit tumor growth in vivo in a CT26 colon cancer mouse xenograft model. Mechanisms of action studies display that Ru1 can favorably accumulate in lysosome and exerts anti-cancer potency by inducing a series of events related to lysosomal dysfunction in CT26 cells. Interestingly, inhibition of lysosomal enzymes leads to suppression of cytotoxicity and apoptosis induced by Ru1. Our results elucidate that complex Ru1 can elicit cytotoxicity through lysosome-mediated apoptosis in vitro and suppress tumor growth in vivo.
Vanadyl cationic complexes as catalysts in olefin oxidation
Nunes, Carla D.,Vaz, Pedro D.,Félix, Vítor,Veiros, Luis F.,Moniz, Tania,Rangel, Maria,Realista, Sara,Mourato, Ana C.,Calhorda, Maria José
, p. 5125 - 5138 (2015/03/18)
Three new mononuclear oxovanadium(iv) complexes [VO(acac)(R-BIAN)]Cl (BIAN = 1,2-bis{(R-phenyl)imino}acenaphthene, R = H, 1; CH3, 2; Cl, 3) were prepared and characterized. They promoted the catalytic oxidation of olefins such as cyclohexene, cis-cyclooctene, and styrene with both tbhp (tert-butylhydroperoxide) and H2O2, and of enantiopure olefins (S(-)- and R(+)-pinene, and S(-)- and R(+)-limonene) selectively to their epoxides, with tbhp as the oxidant. The TOFs for styrene epoxidation promoted by complex 3 with H2O2 (290 mol mol-1V h-1) and for cis-cyclooctene epoxidation by 2 with tbhp (248 mol mol-1V h-1) are particularly good. Conversions reached 90% for several systems with tbhp, and were lower with H2O2. A preference for the internal CC bond, rather than the terminal one, was found for limonene. Kinetic data indicate an associative process as the first step of the reaction and complex [VO(acac)(H-BIAN)]+ (1+) was isolated in an FTICR cell after adding tbhp to 1. EPR studies provide evidence for the presence of a V(iv) species in solution, until at least 48 hours after the addition of tbhp and cis-cyclooctene, and cyclic voltammetry studies revealed an oxidation potential above 1 V for complex 1. DFT calculations suggest that a [VO(H-BIAN)(MeOO)]+ complex is the likely active V(iv) species in the catalytic cycle from which two competitive mechanisms for the reaction proceed, an outer sphere path with an external attack of the olefin at the coordinated peroxide, and an inner sphere mechanism starting with a complex with the olefin coordinated to vanadium. This journal is
Bis(aryl)acenaphthenequinonediimine substituent effect on the properties and coordination environment of ligands and their bis-chelate AgI complexes
Papanikolaou, Panagiotis A.,Gdaniec, Maria,Wicher, Barbara,Akrivos, Pericles D.,Tkachenko, Nikolai V.
, p. 5196 - 5205 (2013/10/22)
The reaction of a series of Ar-BIAN ligands (Ar = o-Ph, m-Cl, m-CF 3, p-Cl, p-MeO, and p-Me-C6H4) with AgNO 3 results in the formation of the corresponding bis-chelate complexes. Substituent groups on the aryl rings seem to offer tunability of the electronic properties of the diimines, also affecting the metal coordination environment through the mono-coordination or chelation of the nitrate anion as promoted by the substituents p-MeO, p-Me, and m-CF3. The enhanced absorption capacity of the complexes in the visible region in combination with the well-known redox activity of the ligands and their ability to potentially accommodate a fifth coordinated ligand on the metal center opens a route for the preparation of new silver species of high propensity for catalytic, photocatalytic, and biological applications. Six new AgI-bis(BIAN) complexes along with their ligands were synthesized and studied. Substituent groups offer tunability of the electronic properties and structural environment of the compounds. The versatility on the metal coordination sphere opens the way for the design of photoactive species with a variety of applications. Copyright
Synthesis and X-ray crystallographic characterization of substituted aryl imines
Kovach, James,Peralta, Maria,Brennessel, William W.,Jones, William D.
experimental part, p. 33 - 38 (2011/07/30)
We report the synthesis of α-diimine 1,4-bis(2,5-di-tert-butylphenyl) -2,3-dimethyl-1,4-diaza-1,3-butadiene, 1, and α-iminoketones 2-[(3,5-xylyl)imino]acenaphthylen-1-one, 4, and 2-[(4-chlorophenyl)imino] acenaphthylen-1-one, 5, all of which have been cha
