153556-42-4

Basic information

• Product Name: 4-Bromo-3-fluorobenzoic acid
• Synonyms: 4-BROMO-3-FLUOROBENZOIC ACID;BUTTPARK 20\01-57;3-Fluoro-4-Bromo Benzoic Acid;4-Bromo-3-fluorobenzoic;4-Bromo-3-fluorobenzoic acid, 98+%;4-Bromo-3-fluorobenzoic acid 98%
• CAS NO: 153556-42-4
• Molecular Formula: C₇H₄BrFO₂
• Molecular Weight: 219.01
• EINECS: 1592732-453-0
• Product Categories: Fluorin-contained Benzoic acid series;blocks;Bromides;Carboxes;FluoroCompounds;Multisubstituted Benzene;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Miscellaneous;Acids & Esters;Bromine Compounds;Fluorine Compounds;Fluorine series
• Mol File: 153556-42-4.mol
• Article Data: 18

Chemical Properties

• Melting Point: 207 °C
• Boiling Point: 296.1 °C at 760 mmHg
• Flash Point: 132.9 °C
• Appearance: white crystal powder
• Density: 1.789 g/cm³
• Vapor Pressure: 0.000663mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.63±0.10(Predicted)
• CAS DataBase Reference: 4-Bromo-3-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-3-fluorobenzoic acid(153556-42-4)
• EPA Substance Registry System: 4-Bromo-3-fluorobenzoic acid(153556-42-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 153556-42-4(Hazardous Substances Data)

Usage

Chemical Properties

White solid powder

InChI:InChI=1/C7H4BrFO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H,10,11)/p-1

Upstream product

• 452-74-4 4-bromo-3-fluorotoluene 
• 304445-49-6 1-(4-bromo-3-fluorophenyl)ethan-1-one 

Downstream Products

• 1416784-79-6 4-{3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-1-yl}-3-fluoro-N-isopropylbenzamide 
• 1416784-30-9 4-{3-(cyanomethyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-1-yl}-3-fluoro-N-isopropylbenzamide 
• 1249540-08-6 4-bromo-3-fluoro-N-isopropylbenzamide 
• 1416784-85-4 4-bromo-3-fluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzamide 
• 1416784-81-0 4-bromo-N-[(1R)-1-cyclopropylethyl]-3-fluorobenzamide 
• 1264616-07-0 C₁₇H₂₅BFNO₃ 
• 1264616-09-2 C₂₃H₃₈B₂FNO₅ 
• 874289-25-5 C₁₁H₁₃BFNO₃ 
• 1264616-14-9 C₁₇H₂₃BFNO₃ 
• 1223432-37-8 (4-bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone 
• 1223432-70-9 4-(4-bromo-3-fluorobenzoyl)piperazine-1-carboxylic acid tert-butyl ester 
• 1223427-38-0 (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one 
• 1223427-36-8 (R)-3-{4-[4-(3,5-dichloropyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-methoxymethyloxazolidin-2-one 
• 1223432-76-5 (R)-3-[2-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one 

Relevant articles and documents

Continuous synthesis method for substituted benzoic acid organic matter

The invention provides a continuous synthesis method for a substituted benzoic acid organic matter. The continuous synthesis method comprises the following steps: in the presence of a catalyst and anorganic solvent, continuously putting an organic matter of a formula (I) shown in the specification, and oxygen into a continuous reaction device, carrying out a continuous oxidation reaction so as toobtain the substituted benzoic acid organic matter, and continuously discharging the substituted benzoic acid organic matter, wherein the substituted benzoic acid organic matter is of a structure ofa formula (II) shown in the specification. Oxygen is a green reagent and is cheap and easy to obtain, a great amount of wastes are not generated after reactions are completed, and the system is easy to treat. Due to continuous reaction operation, the risk that the solvent has flash evaporation explosion because of high-concentration oxygen in in-batch reactions can be reduced. Under same oxidationconditions, due to a continuous preparation process, escape of oxygen can be reduced, the utilization rate of oxygen can be greatly increased, operation can be also simplified, the security of reactions can be improved, and the yield of the substituted benzoic acid organic matter can be increased.

HISTONE DEACETYLASE INHIBITORS

The disclosure provides compounds of formula I and methods for preparation thereof. The compounds act as inhibitor of histone deacetylase.

Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents

A series of novel diaryl ether lactams have been identified as very potent dual inhibitors of protein farnesyltransferase (FTase) and protein geranylgeranyltransferase I (GGTase-I), enzymes involved in the prenylation of Ras. The structure of the complex formed between one of these compounds and FTase has been determined by X-ray crystallography. These compounds are the first reported to inhibit the prenylation of the important oncogene Ki-Ras4B in vivo. Unfortunately, doses sufficient to achieve this endpoint were rapidly lethal.