153562-60-8 Usage
General Description
The chemical "1-[(benzyloxy)methyl]-5-ethyl-6-(pyridin-2-ylselanyl)pyrimidine-2,4(1H,3H)-dione" is a synthetic compound with potential pharmacological applications. It is composed of a pyrimidine-2,4(1H,3H)-dione core with an ethyl group at the 5-position, a pyridin-2-ylselanyl group at the 6-position, and a benzyloxy methyl group at the 1-position. 1-[(benzyloxy)methyl]-5-ethyl-6-(pyridin-2-ylselanyl)pyrimidine-2,4(1H,3H)-dione has potential biological activities due to its pyrimidine core and the presence of the pyridin-2-ylselanyl group, which can potentially interact with cellular targets and produce biological effects. Further research and testing are needed to fully understand the potential pharmacological properties and applications of this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 153562-60-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,5,6 and 2 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 153562-60:
(8*1)+(7*5)+(6*3)+(5*5)+(4*6)+(3*2)+(2*6)+(1*0)=128
128 % 10 = 8
So 153562-60-8 is a valid CAS Registry Number.
153562-60-8Relevant articles and documents
Synthesis and anti-HIV-1 activities of 6-arylthio and 6- arylselenoacyclonucleosides
Pan,Chen,Piras,Dutschman,Rowe,Cheng,Chu -
, p. 177 - 185 (2007/10/02)
6-Arylthio and 6-arylselenoacyclonucleosides was synthesized and tested for the ability to inhibit replication of HIV-1. Lithiation of acyclonucleosides with LDA followed by reaction with the electrophiles phenyl disulfide, diphenyl diselenide, 2,2'-dipyrdyl disulfide or 2,2'-dipyridyl diselenide afforded 6-(arylthio or arylseleno)acyclonucleosides 5a-c, 6, 7, 9, 15a-c, 17a-c. Compounds 19a-c and 20a-c were obtained by deprotection of corresponding TBDMS derivatives. Dehydrated products 16a, and 18a-c were also formed during the reactions. 5-Ethyl-6-(α-pyridylthio or α-pyridylseleno) disubstituted acyclouracils 6 and 7 were more active against HIV-1 in both MT-2 and CEM-IW cell lines than AZT, DDC, DDI or D4T. The EC50 of 6 against HIV-1 in CEM-IW cell was in the nanomolar range with a therapeutic index of 1100.