153649-65-1

Basic information

• Product Name: Propanedioic acid, [(5R)-5-(hydroxymethyl)-2-pyrrolidinylidene]-, bis(phenylmethyl) ester
• CAS NO: 153649-65-1
• Molecular Formula: C22H23NO5
• Molecular Weight: 381.428
• Mol File: 153649-65-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [(5R)-5-(hydroxymethyl)-2-pyrrolidinylidene]-, bis(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [(5R)-5-(hydroxymethyl)-2-pyrrolidinylidene]-, bis(phenylmethyl) ester(153649-65-1)
• EPA Substance Registry System: Propanedioic acid, [(5R)-5-(hydroxymethyl)-2-pyrrolidinylidene]-, bis(phenylmethyl) ester(153649-65-1)

Safety Data

• Hazardous Substances Data: 153649-65-1(Hazardous Substances Data)

Upstream product

• 142890-18-4 (R)-2-[5-(tert-butyldiphenylsiloxy)methylpyrrolidin-2-ylidene]malonic acid dibenzyl ester 
• 66673-40-3 (R)-5-hydroxymethylpyrrolidin-2-one 
• 142890-14-0 (R)-5-(tert-butyldiphenylsiloxy)methylpyrrolidin-2-thione 
• 138629-44-4 (R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-2-one 
• 65100-24-5 dibenzyl 2-bromomalonate 

Downstream Products

• 142890-31-1 (R)-2-(1-azabicyclo[3.1.0]hex-2-ylidene)malonic acid dibenzyl ester 
• 142890-27-5 (R)-2-(5-bromomethylpyrrolidin-2-ylidene)malonic acid dibenzyl ester 
• 142890-26-4 (R)-2-(5-iodomethylpyrrolidin-2-ylidene)malonic acid dibenzyl ester 
• 142890-22-0 (R)-2-(5-p-toluenesulfonyloxymethylpyrrolidin-2-ylidene)malonic acid dibenzyl ester 

Relevant articles and documents

Synthetic studies of carzinophilin. Part 1: Synthesis of 2-methylidene-1-azabicyclo[3.1.0]hexane systems related to carzinophilin

Synthesis of the model compounds of carzinophilin carrying 2-methylidene-1-aza-bicyclo[3.1.0]hexane systems was achieved. Formation of malonylidenes or N-acyl-glycinylidenepyrrolidines was carried out by utilizing Eschenmoser's sulfide contraction or Herdeis's condensation between the 2-methylthio-Δ1-pyrrolone derivatives and ethyl nitroacetate, respectively. The 1-azabicyclo-[3.1.0]hexane systems were constructed by base-promoted aziridine formation.