153668-71-4

Upstream product

• 120205-50-7 N-Boc-(2R,3R,4S)-dolaproine 
• 158189-10-7 (+/-)-Boc-dolaphenine 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 69610-41-9 Boc-L-Pro-H 
• 159173-43-0 (2S,1'R,2'S)-N-(tert-butoxycarbonyl)-2-(1'-methoxy-2'-methyl-3'-butenyl)-pyrrolidine 
• 159173-40-7 (2S,1'R,2'S)-N-(tert-butoxycarbonyl)-2-(1'-hydroxy-2'-methyl-3'-butenyl)-pyrrolidine 
• 133565-36-3 2-<1'-((benzyloxycarbonyl)amino)-2'-phenylethyl>-1,3-thiazole 
• 115186-37-3 tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate 

Downstream Products

• 159248-98-3 Boc-Dil-Dap-(R)-Doe 
• 159248-99-4 Z-Val-Dil-Dap-(R)-Doe 

Relevant academic research and scientific papers

The dolastatins. 22. Synthesis of Boc-dolaproinyl-dolaphenine and four related chiral isomers

Synthesis of the dolastatin 10 (1) dipeptide segment N-(tert-butoxycarbonyl)-dolaproinyl-dolaphenine (2, Boc-Dap-Doe) and four chiral isomers (3-5, 13) has been summarized. Formation of the amide bond was readily accomplished employing diethyl cyanophosph

The dolastatins. 21. Synthesis, X-ray crystal structure, and molecular modeling of (6R)-isodolastatin 10

A practical synthesis of (6R)-isodolastatin 10 (1b) was devised, the X-ray crystal structure was determined, and this chiral isomer was found to have antineoplastic activity comparable to dolastatin 10 (1a).