153707-56-3

Basic information

• Product Name: 3,5-DI(HYDROXYMETHYL)PHENOL
• Synonyms: 3,5-DI(HYDROXYMETHYL)PHENOL;5-hydroxy-1,3-benzenedimethanol;3,5-bis(hydroxymethyl)phenol
• CAS NO: 153707-56-3
• Molecular Formula: C₈H₁₀O₃
• Molecular Weight: 154.16
• Product Categories: pharmacetical
• Mol File: 153707-56-3.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 399.6°Cat760mmHg
• Flash Point: 208.2°C
• Appearance: /
• Density: 1.334g/cm³
• Vapor Pressure: 4.2E-07mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: 3,5-DI(HYDROXYMETHYL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DI(HYDROXYMETHYL)PHENOL(153707-56-3)
• EPA Substance Registry System: 3,5-DI(HYDROXYMETHYL)PHENOL(153707-56-3)

Safety Data

• Hazardous Substances Data: 153707-56-3(Hazardous Substances Data)

Usage

General Description

3,5-DI(HYDROXYMETHYL)PHENOL, also known as resorcinol diglycidyl ether, is a chemical compound that is commonly used in the production of polymer materials and adhesives. It is a clear, colorless liquid with a faint odor and is highly soluble in water. 3,5-DI(HYDROXYMETHYL)PHENOL is known for its ability to form strong and durable bonds with a wide range of materials, making it a valuable component in the manufacture of various industrial and consumer products. It is also used in the synthesis of advanced materials such as composites and coatings, as well as in the production of resins and biodegradable polymers. However, it is important to handle and use this chemical with care, as it can be hazardous to both human health and the environment if not properly managed.

InChI:InChI=1/C8H10O3/c9-4-6-1-7(5-10)3-8(11)2-6/h1-3,9-11H,4-5H2

Upstream product

• 39630-68-7 diethyl 5-hydroxyisophthalate 
• 618-83-7 5-Hydroxyisophthalic acid 
• 249630-39-5 5-(hexadecane-1-sulfonyloxy)-isophthalic acid dimethyl ester 
• 249630-30-6 hexadecane-1-sulfonic acid 3,5-bis-hydroxymethyl-phenyl ester 
• 221648-02-8 di-n-butyl 5-hydroxyisophthalate 
• 13036-02-7 Dimethyl 5-hydroxyisophthalate 

Downstream Products

• 249630-41-9 hexadecane-1-sulfonic acid 3,5-bis-(3,5-bis-hydroxymethyl-phenoxymethyl)-phenyl ester 
• 220830-64-8 {3-[6-(tert-Butyl-diphenyl-silanyloxy)-hexyloxy]-5-hydroxymethyl-phenyl}-methanol 
• 852567-35-2 [3-hydroxymethyl-5-(4'-methyl-[2,2']bipyridinyl-4-ylmethoxy)-phenyl]-methanol 
• 658857-17-1 1-(4,4-dimethoxybutyloxy)-3,5-bis(hydroxymethyl)benzene 
• 144876-14-2 5-hydroxy-benzene-1,3-dicarbaldehyde 
• 434929-06-3 bis(1,1-dimethylethyl) 2,2'-{4-{[3,5-bis(hydroxymethyl)phenoxy]methyl}-1,3-phenylenebis(oxy)}bis[acetate] 
• 220791-17-3 1,1-dimethylethyl [3,5-bis(hydroxymethyl)phenoxy]acetate 
• 186605-76-5 3,5-bis[3,5-bis(methoxycarbonyl)phenoxymethyl]phenol 

Relevant articles and documents

Dendrimeric Sulfanyl Porphyrazines: Synthesis, Physico-Chemical Characterization, and Biological Activity for Potential Applications in Photodynamic Therapy

Sulfanyl porphyrazines substituted at their periphery with different dendrimeric moieties up to their first generation were synthesized and characterized by photochemical and biological methods. The presence of a dendrimeric periphery enhanced the spectral properties of the porphyrazines studied. The singlet-oxygen-generation quantum yield of the obtained macrocycles ranged from 0.02 to 0.20 and was strongly dependent on the symmetry of the compounds and the terminal groups of the dendritic outer shell. The in vitro biological effects of three most promising tribenzoporphyrazines were examined; the results indicated their potential as photosensitizers for photodynamic therapy (PDT) against two oral squamous cell carcinoma cell lines derived from the tongue. The highest photocytotoxicity was found for sulfanyl tribenzoporphyrazine that possessed 4-[3,5-di(hydroxymethyl)phenoxy]butyl substituents with nanomolar IC50 values at 10 and 42 nm against CAL 27 and HSC-3 cell lines, respectively. Topic of cancer: Sulfanyl porphyrazines and tribenzoporphyrazines substituted at their periphery with different dendrimeric moieties up to their first generation were synthesized and characterized by photochemical and biological methods. The in vitro biological effects of three most promising tribenzoporphyrazines were examined and found to exhibit nanomolar IC50 values (see figure).

COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION

The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.

FUSED HETEROCYCLIC BENZODIAZEPINE DERIVATIVES AND USES THEREOF

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.