1537171-89-3Relevant academic research and scientific papers
Palladium-Catalyzed gem-Difluoroallylation Reaction between Aryltributyltin and Bromodifluoromethylated Alkenes
Chen, Chuan-Xin,Chen, Xiao-Qu,Lu, Heng,Shi, Chang-Yun,Wang, Dong-Yu,Zeng, Ruoqing,Zhang, Ao
, (2022/02/10)
A robust Stille gem-difluoroallylation of arylstannanes with 3-bromo-3,3-difluoropropenes has been established. The catalyst was found to exert critical effect on the reaction chemoselectivity. By using Pd(OH)2/C as the catalyst, a series of 3-(hetero)ary
Highly selective gem -difluoroallylation of organoborons with bromodifluoromethylated alkenes catalyzed by palladium
Min, Qiao-Qiao,Yin, Zengsheng,Feng, Zhang,Guo, Wen-Hao,Zhang, Xingang
supporting information, p. 1230 - 1233 (2014/02/14)
A first example of Pd-catalyzed gem-difluoroallylation of organoborons using 3-bromo-3,3-difluoropropene (BDFP) in high efficiency with high α/γ-substitution regioselectivity has been developed. The reaction can also be extended to substituted BDFPs and has advantages of low catalyst loading (0.8 to 0.01 mol %), broad substrate scope, and excellent functional group compatibility, thus providing a facile route for practical application in drug discovery and development.
