1537176-76-3Relevant academic research and scientific papers
Discovery of short peptides exhibiting high potency against Cryptococcus neoformans
Mahindra, Amit,Bagra, Nitin,Wangoo, Nishima,Khan, Shabana I.,Jacob, Melissa R.,Jain, Rahul
, p. 315 - 320 (2014/05/06)
Rapid increase in the emergence of resistance against existing antifungal drugs created a need to discover new structural classes of antifungal agents. In this study we describe the synthesis of a new structural class of short antifungal peptidomimetcis, their activity, and plausible mechanism of action. The results of the study show that peptides 11e and 11f are more potent than the control drug amphotericin B, with no cytotoxicity to human cancer cells and noncancerous mammalian kidney cells. The selectivity of peptides to fungus is depicted by transmission electron microscopy studies, and it revealed that 11e possibly disrupts the model membrane of the fungal pathogen.
Synthesis and antimicrobial activities of His(2-aryl)-Arg and Trp-His(2-aryl) classes of dipeptidomimetics
Mahindra, Amit,Sharma, Krishna K.,Rathore, Dinesh,Khan, Shabana. I.,Jacob, Melissa R.,Jain, Rahul
, p. 671 - 676 (2014/05/06)
In this communication, we report the design, synthesis and in vitro antimicrobial activity of ultra short peptidomimetics. Besides producing promising antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), the dipeptidomimetics exhibited high antifungal activity against C. neoformans with IC50 values in the range of 0.16-19 μg mL-1. The most potent analogs exhibited 4-fold higher activity than the currently used drug amphotericin B, with no apparent cytotoxicity in a panel of mammalian cell lines. This journal is the Partner Organisations 2014.
